Las lesiones en la piel producidas por el lupus eritematoso sistémico constituyen una de las manifestaciones más frecuentes de esta enfermedad. Estas lesiones muestran una gran variabilidad, tanto en su expresión clínica como histológica, lo que dificulta su comprensión y estudio. Los pacientes que cursan con lupus cutáneo no necesariamente tienen complicaciones sistémicas graves, pero sí importante morbilidad por afección en la calidad de vida dada la extensión de las lesiones, tendencia a la cronicidad y el riesgo de cicatrices; de ahí la importancia de instaurar un tratamiento rápido y eficaz. El presente trabajo aborda las diferentes variedades de lesiones específicas atribuidas al lupus eritematoso, su correlación con actividad sistémica, calidad de vida y los tratamientos disponibles.
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