Ralph M. Steinman fue galardonado con el Premio Nobel de Fisiología y Medicina 2011 por su descubrimiento de las células dendríticas, fundamentales en la inducción de respuestas inmunológicas adquiridas necesarias para la defensa del organismo. Actualmente las células dendríticas se han aprovechado para el desarrollo de vacunas y terapia oncológica.
Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973;137(5): 1142-1162. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139237/pdf/1142.pdf
Cheong C, Choi JH, Vitale L, He LZ, Trumpfheller C, Bozzacco L, et al. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood 2010;116(19):3828-3838. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981538/? tool=pubmed
Palucka AK, Paczesny S, Dhodapkar MV, Steinman RM, Fay JW, Banchereau J Dendritic cells as melanoma vaccines. J Invest Med 2003;51(Supl 2):S385-S386.
Banchereau J, Palucka AK, Dhodapkar M, Burkeholder S, Taquet N, Rolland A, et al. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res 2001;61(17): 6451-6458.
Palucka AK, Dhodapkar MV, Paczesny S, Burkeholder S, Wittkowski KM, Steinman RM, et al. Single injection of CD34+ progenitor- derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma. J Immunother 2003;26(5):432-439.
Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002;196(12):1627-1638. Disponible en http://www.ncbi. nlm.nih.gov/pmc/articles/PMC2196060/?tool=pubmed
Bonifaz LC, Bonnyay DP, Charalambous A, Darguste DI, Fujii SI, Soares H, et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med 2004;199(6):815-824. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212731/?tool=pubmed