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Candiduria en pacientes con diabetes mellitus tipo 2. Sensibilidad antifúngica in vitro
Resumen
Introducción: la presencia de Candida en orina de pacientes diabéticos es muy frecuente. El objetivo de la investigación fue determinar la presencia y el significado clínico de candiduria, identificar las diferentes especies
aisladas de Candida y su patrón de sensibilidad invitro a diferentes antifúngicos, por el método de microdilución en caldo.
Material y métodos: se estudió la orina de 50 pacientes con diabetes mellitus tipo 2, 24 de los pacientes en control y 26 pacientes no controlados.
Resultados: se obtuvieron 23 aislamientos de Candida spp., de los cuales 17 fueron obtenidos de pacientes no controlados; 30.7 % de los aislamientos fue causa de candiduriainfección. La principal especie aislada fue C. glabrata (48 %) seguida de C. albicans (35 %). Itraconazol, anfotericina B y ketoconazol presentaron menor actividad antifúngica en los aislamientos de C. glabrata, mientras que fluconazol y voriconazol mayor.
Conclusiones: es importante realizar la búsqueda rutinaria de levaduras en la orina de los pacientes con diabetes mellitus tipo 2, para detectar candiduria y efectuar estudio de sensibilidad antifúngica a los aislamientos de Candida para establecer un tratamiento oportuno y efectivo.
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