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Células tumorales circulantes en cáncer de mama

Eunice López-Muñoz, Gabriel Enrique Mejía-Terrazas

Resumen


El cáncer de mama es el cáncer más recurrente en la población femenina, su mortalidad se relaciona con la presencia de metástasis a distancia. La metástasis a distancia inicia como un pequeño grupo de células que se diseminan a nivel regional y a distancia del sitio de origen primario. Las células tumorales circulantes (CTC) están presentes en la sangre de las pacientes con cáncer, por lo que se consideran marcadores de enfermedad y precursoras de metástasis. Es transcendental la revisión de los aspectos moleculares del proceso metástasico, las técnicas disponibles para el enriquecimiento, identificación y caracterización molecular de CTC, así como algunos ejemplos de su utilidad y aplicación clínica en pacientes con cáncer de mama, incluyendo aspectos relacionados con el manejo perioperatorio durante la cirugía oncológica mamaria.


Palabras clave


Neoplasias de la Mama; Células Neoplásicas Circulantes; Metástasis de la Neoplásia; Biomarcadores.

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Referencias


 

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DOI: https://doi.org/10.24875/RMIMSS.M20000115

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