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Células tumorales circulantes en cáncer de mama / Circulating tumor cells in breast cancer
Resumen
Resumen
El cáncer de mama es el cáncer más recurrente en la población femenina, su mortalidad se relaciona con la presencia de metástasis a distancia. La metástasis a distancia inicia como un pequeño grupo de células que se diseminan a nivel regional y a distancia del sitio de origen primario. Las células tumorales circulantes (CTC) están presentes en la sangre de las pacientes con cáncer, por lo que se consideran marcadores de enfermedad y precursoras de metástasis. Es transcendental la revisión de los aspectos moleculares del proceso metástasico, las técnicas disponibles para el enriquecimiento, identificación y caracterización molecular de CTC, así como algunos ejemplos de su utilidad y aplicación clínica en pacientes con cáncer de mama, incluyendo aspectos relacionados con el manejo perioperatorio durante la cirugía oncológica mamaria.
Abstract
Breast cancer is the most recurrent cancer in female population, its mortality is related to the presence of distant metastases. Distant metastasis begins as a small group of cells that spread regionally and remotely from the site of primary origin. Circulating tumor cells (CTC) are present in the blood of cancer patients and are therefore considered disease markers and precursors of metastasis. It is trascendental the review of the molecular aspects of the metastatic process, the available techniques for the enrichment, identification and molecular characterization of CTC, as well as some examples of its usefulness and clinical application in patients with breast cancer, including aspects related to perioperative management during breast cancer surgery.
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Referencias
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DOI: https://doi.org/10.24875/RMIMSS.M20000115
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