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Evidencia científica de la relación entre depresión y cáncer de mama: revisión sistemática / Scientific evidence of the relation between breast cancer and depression: systematic review

Damaris Estrella-Castillo, Roberto Carlos Pech-Argüelles, Ingrid Olais-Arjona, Hector Rubio-Zapata, Yelda Aurora Leal-Herrera



El cáncer de mama es la neoplasia maligna más frecuente en mujeres en todo en el mundo. Su diagnóstico y tratamiento puede estar acompañado de síntomas depresivos. La frecuencia de depresión en mujeres con cáncer de mama puede ser tan variada que va desde < 10% a > 70%, dependiendo del instrumento de evaluación, el tipo de población estudiada y el área geográfica. Se ha descrito que la depresión se asocia a factores genético-ambientales; desequilibrio entre los sistemas nervioso central, endócrino e inmunitario; edad de la paciente; presencia de metastasis; quimioterapia, y rehabilitación física. Su tratamiento está basado en diversos tipos de abordajes, como hipnosis, meditación, musicoterapia y manejo del estrés. En México se ha estudiado poco esta relación. El objetivo de este trabajo es realizar una revisión crítica sobre la evidencia científica de la relación entre depresión y cáncer de mama.


Breast cancer is the most frequent malignancy in women around the world. Its diagnosis and treatment may be accompanied by depressive symptoms. The frequency of depression in women with breast cancer may vary, ranging from <  10% to  >  70%, depending on the questionnaire, type of population studied and geographic area. Depression is associated with genetic and environmental factors; the imbalance between the central nervous, endocrine and immune systems; the patient’s age at diagnosis of cancer; metastasis; chemotherapy, and physical rehabilitation. Depression treatment is based on different types of approaches, such as hypnosis, meditation, music therapy and stress management. In Mexico, there are few studies about this topic. The objective of this work is to make a critical review on the scientific evidence of the relation between depression and breast cancer.

Palabras clave

Depresión; Cáncer de Mama; Psicooncología / Depression; Breast Cancer; Psycho-Oncology

Texto completo:




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