Resumen
Introducción: La presencia de lesión renal aguda se ha asociado a unas mayores morbilidad y mortalidad de causa cardiovascular (muerte súbita y arritmias).
Objetivo: Conocer la frecuencia de trastornos del ritmo cardiaco documentado por Holter en pacientes con necesidad de hemodiálisis intermitente por lesión renal aguda.
Material y métodos: Se realizó un estudio observacional, prospectivo, en pacientes con diagnóstico de lesión renal aguda que recibieron hemodiálisis intermitente; se recabaron datos demográficos, clínicos y de laboratorio de 28 pacientes. Se realizó monitoreo mediante Holter, previo, durante y posterior a la sesión de hemodiálisis. Se utilizó estadística no paramétrica, con un valor significativo de p < 0.05. Se establecieron riesgos con regresión logística.
Resultados: Hubo diferencia significativa en extrasístoles supraventriculares (82.1% frente a 57.1%), extrasístoles ventriculares (26.7% frente a 3.6%) y taquicardia supraventricular (6.7% frente a 3.6%). El resto de las alteraciones del ritmo no mostraron significancia.
Conclusiones: La hemodiálisis intermitente es un factor asociado a la aparición de trastornos del ritmo cardiaco. La muerte de los pacientes con lesión renal aguda y sustitución estuvo relacionada con la extrasístole ventricular detectada por Holter transhemodiálisis.
Abstract
Background: The presence of acute renal injury has been associated with increased cardiovascular morbidity and mortality (sudden death and arrhythmias).
Objective: To know the frequency of heart rhythm disorders documented by Holter in patients in need of intermittent hemodialysis due to acute renal injury.
Material and methods: A prospective observational study was conducted including patients with a diagnosis of acute renal injury who received intermittent hemodialysis; demographic, clinical and laboratory data were collected from 28 patients. Monitoring was carried out through Holter before, during and after the hemodialysis session. Nonparametric statistics were used, with a significant value of p < 0.05. Risks were established with logistic regression.
Results: There was a significant difference in supraventricular extra systoles (82.1% vs. 57.1%), ventricular extra systoles (26.7% vs. 3.6%), and supraventricular tachycardia (6.7% vs. 3.6%). The rest of the rhythm alterations without significance.
Conclusions: Intermittent hemodialysis is a factor associated with the appearance of heart rhythm disorders. The death of patients with acute renal injury and substitution was related to ventricular extra systole detected by transhemodialysis Holter.
León C, Cieza J, Valenzuela R. Injuria renal aguda, perfil epidemiológico intrahospitalario y factores asociados al riesgo de muerte. Rev Med Hered. 2014;25:189-95.
Díaz M, Briones J, Basilio A. Insuficiencia renal aguda (IRA) y terapia de reemplazo renal temprano (TRR). Rev Asoc Mex Med Crit Ter Int. 2013;27(4):237-44.
Bhatti N, Karimi K, Paz Y, Nazif T, Moses J, León M, et al. Diagnosis and management of cardiovascular disease in advanced and end-stage renal disease. J Am Heart Assoc. 2016;5(8):1-14.
Cheung A, Sarnak M, Yan G, Berkoben M, Heyka R, Kaufman A, et al. Cardiac diseases in maintenance hemodialysis patients:results of the HEMO Study. Kidney Int. 2004;65(6):2380-9.
Wander G, Sandha G, Chhabra S, Khaira N, Chinna R. Holter monitoring in chronic renal failure before and during dialysis. J Assoc Physicians India. 1994;42(9):743.
De Lima J, Lopes H, Grupi C, Abensur H, Giorgi M, Krieger E, et al. Blood pressure influences the occurrence of complex ventricular arrhythmia in hemodialysis patients. Hypertension. 1995;6:1200-3.
Gruppo Emodialisi e Patologie Cardiovasculari. Multicentre, cross-sectional study of ventricular arrhythmias in chronically haemodialysed patients. Lancet. 1988;2(↞):305-9.
Shapira O, Bar-Khayim Y. ECG changes and cardiac arrhythmias in chronic renal failure patients on hemodialysis. J Electrocardiol. 1992;25(4):273-9.
Verde E, Pérez de Prado A, López-Gómez J, Quiroga B, Goicoechea M, García-Prieto A, et al. Asymptomatic intradialytic supraventricular arrhythmias and adverse outcomes in patients on hemodialysis. Clin J Am Soc Nephrol. 2016;11(12):2210-7.
Aviles R, Martin D, Apperson-Hansen C, Houghtaling P, Rautaharju P, Kronmal R, et al. Inflammation as a risk factor for atrial fibrillation. Circulation. 2003;108(24):3006-10.
Zimmerman D, Sood M, Rigatto C, Holden R, Hiremath S, Clase C. Systematic review and meta-analysis of incidence, prevalence and outcomes of atrial fibrillation in patients on dialysis. Nephrol Dial Transplant. 2012;27(10):3816-22.
Buiten M, de Bie M, Rotmans J, Gabreëls B, van Dorp W, Wolterbeek R, et al. The dialysis procedure as a trigger for atrial fibrillation:new insights in the development of atrial fibrillation in dialysis patients. Heart. 2014;100(9):685-90.
Claure-Del Granado R, Bouchard J. Acid-base and electrolyte abnormalities during renal support for acute kidney injury:recognition and management. Blood Purif. 2012;34(2):186-93.
Vázquez E, Sánchez-Perales C, García-García F, Castellano P, García-Cortes MJ, Liebana A, et al. Atrial fibrillation in incident dialysis patients. Kidney Int. 2009;76(3):324-30.
Abe S, Yoshizawa M, Nakanishi N, Yazawa T, Yokota K, Honda M, et al. Electrocardiographic abnormalities in patients receiving hemodialysis. Am Heart J. 1996;131(6):1137-44.
Buiten M, de Bie M, Rotmans J, Gabreëls B, Jukema J, Rabelink T, et al. The dialysis procedure as a trigger for atrial fibrillation:new insights in the development of atrial fibrillation in dialysis patients. Heart. 2014;100(9):685-90.
Wizemann V, Kramer W, Funke T, Shuttede G. Dialysis-induced cardiac arrhythmias:fact or fiction?Nephron. 1985;39(4):356-60.
Palma-Gámiz J, Arribas-Jiménez A, González-Juanatey JR. Guías de práctica clínica de la Sociedad Española de Cardiología en la monitorización ambulatoria del electrocardiograma y presión arterial. Rev Esp Cardiol. 2000;53(1):91-109
Furuland H, Linde T, Englund A, Wikström B. Heart rate variability is decreased in chronic kidney disease but may improve with hemoglobin normalization. J Nephrol. 2008;21(1):45-52.
Redaelli B, Locatelli F, Limido D, Andrulli S, Signorini MG, Sforzini S, et al. Effect of a new model of hemodialysis potassium removal on the control of ventricular arrhythmias. Kidney Int. 1996;50(2):609-17.
Choi JS, Kim YA, Kim HY, Oak CY, Kang YU, Kim CS, et al. Relation of serum potassium level to long-term outcomes in patients with acute myocardial infarction. Am J Cardiol. 2014;113(8):1285-90.