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La AMPK como blanco terapéutico del síndrome metabólico.

Gerardo Hernández Puga, Kevin David Laguna Maldonado, Raul Gergg García, Giselle Barrera Zárate, David Feliciano López Ortíz, Deyamira Matuz Mares

Resumen


La cinasa activada por AMP (AMPK) es una enzima crucial en la regulación del metabolismo energético celular, cuya actividad se encuentra regulada por diversos mecanismos, siendo el principal el aumento en la concentración intracelular de AMP. Esta enzima cataliza la fosforilación de múltiples proteínas reguladoras de las vías metabólicas de lípidos y carbohidratos, favoreciendo su catabolismo. Debido a esto, tiene un rol importante en la fisiopatología de enfermedades como el síndrome metabólico y la diabetes mellitus 2, las cuales tienen una alta prevalencia en la población mexicana. En vista de lo anterior, la AMPK se ha convertido en un blanco relevante donde actúan diversos fármacos utilizados en el manejo de estas patologías, como es el caso de la metformina y las tiazolidinedionas.


Palabras clave


Síndrome metabólico; diabetes mellitus tipo 2; AMPK; metformina.

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Referencias


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