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Síndrome autoinmune/inflamatorio inducido por adyuvantes. ¿Una nueva entidad clínica?
Resumen
Recientemente Shoenfeld y Agmon-Levin han propuesto una nueva entidad clínica denominada síndrome autoinmune/inflamatorio inducido por adyuvantes (ASIA, por sus siglas en inglés), el cual incluye cuatro entidades denominadas: 1) siliconosis, 2) síndrome de la guerra del Golfo, 3) miofascitis macrofágica y 4) fenómeno posvacunación asociado a adyuvantes. Todos ellos tienen un denominador común: una exposición previa a inmunoadyuvantes y además comparten varios criterios clínicos asociados a inflamación crónica y reacciones autoinmunes. Esta propuesta aún debe ser validada por la comunidad científica, pero hoy en día es un tema de intenso debate en la literatura biomédica y en varias conferencias internacionales. En esta revisión, se analizan las características de este síndrome, los mecanismos actuales posiblemente implicados en la patogénesis y los más recientes informes sobre ASIA asociada a vacunas y a algunas sustancias extrañas.
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Referencias
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