[Effect of exercise on the serum concentrations of leptin and adiponectin in adolescents with risk factors of developing diabetes]

Rev Med Inst Mex Seguro Soc. 2017 Nov-Dec;55(6):708-714.
[Article in Spanish]

Abstract

Background: Type 2 diabetes mellitus (T2DM) is an increasing health issue. Physical activity (PA) in early stages is a preventive measure in the development of degenerative diseases. It has been documented the association between exercise and leptin and adiponectin concentrations. The objective was to evaluate the effect of a physical activity program (PAP) on serum leptin and adiponectin in teenagers with risk factors for developing T2DM.

Methods: Experimental-longitudinal study. Teenagers (men and women), with T2DM risk factors, aged 14 to 16 years, participated in a PAP for three months, five days a week, 45 minutes each day. Before and after the program, all anthropometric variables, incluiding leptin and adiponectin, were evaluated.

Results: 22 adolescents participated in the PAP and they were compared with 22 adolescents from the control group (who did not participate in the PAP). There was a reduction in the serum concentration of leptin in the intervention group (baseline 23 ± 13; after the PAP 14 ± 8, p > 0.0001), compared with the control group (baseline 18 ± 13, three months follow-up 20 ± 14, p < 0.520). Also, the adiponectin concentration increased (baseline 10 ± 3, after the PAP 13 ± 4.0, p > 0.014), compared with the control group (baseline 11 ± 3, 13 ± 4.0 after the PAP p > 0.032).

Conclusions: This study support the efficacy of an aerobic exercise intervention on metabolic markers of adolescents with risk factors for developing diabetes.

Introducción: la diabetes mellitus tipo 2 (DM2) es un problema de salud cada vez más preocupante. El ejercicio en etapas tempranas es una medida preventiva en el desarrollo de enfermedades crónico-degenerativas. Se ha postulado la asociación entre el ejercicio con las concentraciones de leptina y adiponectina. El objetivo fue evaluar el efecto de un programa de actividad física (AF) sobre la concentración sérica de leptina y adiponectina en adolescentes con factores de riesgo para el desarrollo de DM2.

Métodos: estudio de tipo experimental-longitudinal. Participaron en un programa de AF durante tres meses adolescentes de 14 a 16 años, con factores de riesgo para el desarrollo de diabetes, cinco días a la semana, durante 45 minutos. Antes y después del programa, se evaluó la respuesta de leptina y adiponectina.

Resultados: participaron 22 adolescentes en el programa y se compararon con 22 adolescentes del grupo control. Las cifras de leptina disminuyeron en el grupo de intervención: basal 23 ± 13, después del programa 14 ± 8, p < 0.001; grupo control: basal 18 ± 13, seguimiento a tres meses 20 ± 14, p < 0.520. Asimismo, incrementaron las cifras de adiponectina: basal 10 ± 3, después del programa 13 ± 4.0, p < 0.014; grupo control: basal 11 ± 3, post ejercicio 13 ± 4.0, p < 0.032.

Conclusiones: nuestros resultados apoyan la eficacia de una intervención con ejercicio aeróbico sobre las características en un grupo minoritario de adolescentes con factores de riesgo para desarrollar diabetes.

Keywords: Adiponectin; Leptin; Diabetes Mellitus Type 2; Adolescent; Exercise.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adiponectin / blood*
  • Adolescent
  • Biomarkers / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Exercise / physiology*
  • Exercise Therapy*
  • Female
  • Humans
  • Leptin / blood*
  • Longitudinal Studies
  • Male
  • Prospective Studies
  • Risk Factors
  • Treatment Outcome

Substances

  • Adiponectin
  • Biomarkers
  • Leptin