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Quimiotaxis y enfermedad

Sara Rojas-Dotor, Julia Pérez-Ramos, Ma Guadalupe Rico-Rosillo


La quimiotaxis es la habilidad de las células vivas para determinar la dirección de su locomoción a lo largo de un gradiente de concentración de sustancias atractantes o repelentes. En la presente investigación se describen sustancias como el complemento y sus componentes, así como otros mediadores solubles que causan quimiotaxis (citocinas/quimiocinas) y su relación con algunas enfermedades.

Palabras clave

Quimiotaxis; Fagocitos; Inflamación; Citocinas

Texto completo:



Abbas AK, Lichtman AH. Cellular and molecular immunology. Fifth edition. Philadelphia: Saunders Elsevier; 2004. p. 243-274. 


Wilkinson PC. Chemotaxis and inflammation. London, UK: Churchill Livingstone; 1982. p. 1-34.


Chollet-Martin S, Gougerot-Pocidalo MA. Hereditary polymorphonuclear neutrophil deficiencies. Transfus Clin Biol 2000;7(6):533-539. 


Roitt IM. Immunology. Fifth edition. London, UK: Mosby; 1998. p. 61-69. 


Schiffman E. Leukocyte chemotaxis. Annu Rev Physiol 1982;44:553-568.


Snyderman R, Goetzl EJ. Molecular and cellular mechanisms of leukocyte chemotaxis. Science 1981;213(4510):830-837. 


Kobayashi K. Adhesion molecules and leukocyte functions. Rinsho Byori 1995;43(7):665-668. 


Prieschl EE, Kulmburg PA, Baumruker T. The nomenclature of chemokines. Int Arch Allergy Immunol 1995;107(4):475-483. 


Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182(4):1169- 1174. 


Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 1983;220(4597):568-575. 


La Rosa GJ, Thomas KM, Kaufmann ME, Mark R, White M, Taylor L, et al. Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity. J Biol Chem 1992;267(35):25402-25406. 


Leonard EJ, Skeel A, Yoshimura T, Rankin J. Secretion of monocyte chemoattractant protein-1 (MCP-1) by human mononuclear phagocytes. Adv Exp Med Biol 1993;351:55-64. 


Gerish G. Chemotaxis in Dictyostellium. Ann Rev Physiol 1982;44:535-552.


Bullard DC. Adhesion molecules in inflammatory diseases: insights from knockout mice. Immunol Res 2002;26(1-3):27-33.


Johnston A, Gudjonsson J, Sigmunsdottir H, Ludviksson B, Valdimarsson H. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 2005;114(2):154-163.


Yonekawa K, Harlan J. Targeting leukocyte integrins in human diseases. J Leukoc Biol 2005;77(2):129-140.


Bunting M, Harris ES, McIntyre TM, Prescott SM, Zimmerman GA. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr Opin Hematol 2002;9(1):30-35.


Ward DM, Shiflett SL, Kaplan J. Chediak-Higashi syndrome: a clinical and molecular view of a rare lysosomal storage disorder. Curr Mol Med 2002;(5)2:469-477. 


Boocock Gr, Morrison JA, Popovic M, Richards N, Ellio L, Durrie PR, et al. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat Genet 2003;33(1):97-101.


Gerard C, Hugli TE. Identification of classical anaphylatoxin as the C5a molecule: evidence of a modulator role for the olysaccharide united in human des-arg 74 C5a. Proc Natl Acad Sci 1981; 78(3):1833-1837.


Marder SR, Chenoweth DE, Goldstein IM, Pérez HD. Chemotactic response of human peripheral blood monocyte to the complement-derived C5a-des-Arg. J Immunol 1985;134(5):3325-3331.


Kolakowski LF Jr, Lu B, Gerard C, Gerard NP. Probing the “message: address” sites for chemo-attractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments. J Biol Chem 1995;270 (30):18077-18082. 


FaIk W, Leonard EJ. Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. Infect Immunol 1980;29(3):953-959. 


Daffern PJ, Pfeifer PH, Ember JA, HugIi TE. C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation. J Exp Med 1995 181(6):2119-2127. 


Mrowietz U, Jurgens G. A method for the determination of leukocyte migration for large sample numbers by automated densitometry quantification. J Biochem Biophys Methods 1995;30(1):49-58. 


Altman L, Snyderman R, Oppenheim J, Mergenhagen S. A human mononuclear leukocyte chemotatic factor. Characterization specificity and kinetics of production by homologous leukocytes. J Immunol 1973;110(3):801-810.


Cyster JG. Chemokines and cell migration in secondary lymphoid organs. Science 1999;286(5447): 2098-2102.


Nikel R, Beck LA, Stellato C, Schleimer R. Chemo-kines and allergic disease. J Allergy Clin Immunol 1999;104(4 Pt 1):723-742.


Kraver T, Vilcek J, Oppenheim JJ. Proinflammatory cytokines. En: Paul WE, editor. Fundamental immunology. Fourth edition. Philadelphia: Lippincott Raven; 1999. p. 775-811.


Ip W, Wong CK, Wang CB, Tian YP, Lam CW. Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor induce adhesion and chemotaxis of human eosinophils via p38 mitogen-activated protein kinase and nuclear factor kappa. Immunopharmacol Immunotoxicol 2005;27(3): 371-393.


Randolph D, Huang G, Carruthers C, Bromley L, Chaplin D. The role of CCR7 in Th1 and TH2 cell localization and delivery of B cell help in vivo. Science 1999;286(5447):2159-2162.


Loetscher P, Ugoccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, et al. CCR5 is characteristic of Th1 lymphocytes. Nature 1998;391(6665):344-345.


Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlarzzi CT, Sinigaglia F, et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol 1998;161(2):547-551.


Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister R, Menz G, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158(7):3539-3544.


Lai CK, Ho SS, Chan CH, Leung R, Lai KN. Gene expression of interleukin-3 and granulocyte macro-phage colony-stimulating factor in circulating CD4+ T cells in acute severe asthma. Clin Exp Allergy 1996;26(2):138-146.


Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17(3):138-146.


Luster AD. Chemokines: chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338(7):436-445.


Berin MC, Eckmann L, Broide DH, Kagnoff MF. Regulated production of the helper 2-type T cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol 2001;24(4):382-389.


Lazcano MD, Negrete GMC, Montes VAR, Valencia ME, García-Sancho FC, Franco MF, et al. La quimiocina regulada activada del timo (TARC) se libera en las vías aéreas de pacientes asmáticos. Rev Inst Nal Enf Resp Mex 2002;15(4):201-205.


Cano Londoño NF, Montoya-Guarin CJ. Las quimioquinas: citocinas proinflamatorias y reguladoras del tráfico celular. Iatreia 2001;14(1):57-72.

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