ISSN: 0443-511
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Dolor crónico en pacientes con cáncer de mama / Chronic pain in patients with breast cancer

Gabriel Enrique Mejía-Terrazas, Eunice López-Muñoz



El cáncer de mama es el cáncer más frecuente en la mujer. Aun cuando la mayoría de las mujeres diagnosticadas con cáncer de mama sobreviven, muchas de ellas experimentan dolor como parte del proceso de enfermedad o como un efecto colateral de los procedimientos diagnósticos o terapéuticos. Dado que el dolor crónico en las pacientes con cáncer de mama es una experiencia compleja, el objetivo de este artículo fue realizar una revisión narrativa de la literatura científica disponible en la base datos PubMed en idioma inglés entre enero de 2000 y septiembre de 2019 sobre la epidemiología, factores de riesgo, características clínicas, estrategias preventivas y tratamiento del dolor crónico en pacientes con cáncer de mama, ya que el conocimiento de estos aspectos es trascendental para identificar, tratar y vigilar a las pacientes a largo plazo, a fin de evitar una mayor afectación en su calidad de vida, ya de por sí alterada.


Breast cancer is the most frequent cancer in women. Even though most women diagnosed with breast cancer survive, many of them experience pain as part of the disease process or as a side effect of diagnostic or therapeutic procedures. Given that chronic pain in patients with breast cancer is a complex experience, the objective of this article was to conduct a systematic review of the scientific literature available in the PubMed database in English language between January 2000 and September 2019 on the epidemiology, risk factors, clinical characteristics, preventive strategies and treatment of chronic pain in patients with breast cancer, since the knowledge of these aspects is transcendental to identify, treat and monitor patients in the long term, in order to avoid further impact on their quality of life, already altered.

Palabras clave

Neoplasias de la mama; Dolor Crónico; Neuralgia; Dolor Posoperatorio / Breast Neoplasms; Chronic Pain; Neuralgia; Pain, Postoperative

Texto completo:




Cronin-Fenton DP, Norgaard M, Jacobsen J, Garne JP, Ewertz M ,Lash TL, et al. Comorbidity and survival of Danish breast cancer patients from 1995 to 2005. Br J Cancer. 2007;96(9):1462-8. doi: 10.1038/sj.bjc.6603717.


Mouridsen HT, Bjerre KD, Christiansen P, Jensen MB, Moller S. Improvement of prognosis in breast cancer in Denmark 1977-2006, based on the nationwide reporting to the DBCG Registry. Acta Oncol. 2008;47(4):525-36. doi: 10.1080/02841860802027009.


Costa WA, Monteiro MN, Queiroz JF, Goncalves AK. Pain and quality of life in breast cancer. Clinics (Sao Paulo). 2017;72(12):758-63. doi: 10.6061/clinics/2017(12)07.


Bao T, Seidman A, Li Q, Seluzicki C, Blinder V, Meghani SH, et al. Living with chronic pain: perceptions of breast cancer survivors. Breast Cancer Res Treat. 2018;169(1):133-40. doi: 10.1007/s10549-018-4670-9.


Mejdahl MK, Andersen KG, Gärtner R, Kroman N, Kehlet H. Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study. BMJ. 2013;346:f1865. doi: 10.1136/bmj.f1865.


Jung BF, Ahrendt GM, Oaklander AL, Dworkin RH. Neuropathic pain following breast cancer surgery: proposed classification and research update. Pain. 2003;104(1- 2):1-13.


Couceiro TC, Menezes TC, Valenca MM. Post-mastectomy pain syndrome: the magnitude of the problem. Rev Bras Anestesiol. 2009;59(3):358-65.


Gahm J, Wickman M, Brandberg Y. Bilateral prophylactic mastectomy in women with inherited risk of breast cancer--prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast. 2010;19(6):462-9. doi: 10.1016/j.breast.2010.05.003.


Brummett CM. Chronic pain following breast surgery. Tech Reg Anesth Pain Manag. 2011;15:124-32. doi.10.1053/j.trap.2011.07.001.


Romero A, Torà-Rocamora I, Baré M, Barata T, Domingo L, Ferrer J, et al. Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs. BMC Cancer. 2016:16(1);735-84. doi 10.1186/s12885-016-2768-1.


Beyaz SG, Ergönenc JS, Ergönenc T, Sönmez ÖU, Erkorkmaz Ü, Altintoprak F. Postmastectomy pain: A cross-sectional study of prevalence, pain characteristics, and effects on quality of life. Chin Med J (Engl). 2016:129(1):66-71. doi: 10.4103/0366-6999.172589.


Meijuan Y, Zhiyou P, Yuwen T, Ying F, Xinzhong C. A retrospective study of postmastectomy pain syndrome: incidence, characteristics, risk factors, and influence on quality of life. ScientificWorldJournal. 2013;2013:159732. doi: 10.1155/2013/159732.


Bokhari FN, McMillan DE, McClement S, Daeninck PJ. Pilot study of a survey to identify the prevalence of and risk factors for chronic neuropathic pain following breast cancer surgery. Oncol Nurs Forum. 2012:39(2):E141-9. doi: 10.1188/12.ONF.E141-E149.


Juhl AA, Christiansen P, Damsgaard TE. Persistent pain after breast cancer treatment: a questionnaire-based study on the prevalence, associated treatment variables, and pain type. J Breast Cancer. 2016;19(4):447-54. doi: 10.4048/jbc.2016.19.4.447.


Kurita GP, Sjogren P. Pain management in cancer survivorship. Acta Oncol. 2015;54(5):629-34. doi: 10.3109/0284X.2014.996662.


Schou Bredal I, Smeby NA, Ottesen S, Warncke T, Schlichting E. Chronic pain in breast cancer survivors: comparison of psychosocial, surgical, and medical characteristics between survivors with and without pain. J Pain Symp Manag. 2014;48(5):852-62. doi: 10.1016/j.jpainsymman.2013.12.239. 


Gärtner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302(18):1985-92. doi: 10.1001/jama.2009.1568.


Forsythe LP, Alfano CM, George SM, McTieman A, Baumgartner KB, Bernstein L, et al. Pain in long-term breast cancer survivors: the role of body mass index, physical activity, and sedentary behavior. Breast Cancer Res Treat. 2013;137(2):617-30. doi: 10.1007/s10549-012-2335-7.


Johannsen M, Christensen S, Zachariae R, Jensen AB. Socio-demographic, treatment-related, and health behavioral predictors of persistent pain 15 months and 7-9 years after surgery: a nationwide prospective study of women treated for primary breast cancer. Breast Cancer Res Treat. 2015;152(3):645-58. doi: 10.1007/s10549-015-3497-x.


Alves Nogueira E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahäo K, da Costa Leite Ferreira MG, et al. Post-mastectomy pain syndrome: incidence and risks. Breast. 2012;21(3):321-5. doi: 10.1016/j.breast.2012.01.019.


Wang L, Guyatt GH, Kennedy SA, Romerosa B, Kwon HY, Kaushal A, et al. Predictors of persistent pain after breast cancer surgery: a systematic review and meta-analysis of observational studies. CMAJ. 2016;188(14):E352-61. doi: 10.1503/cmaj.151276.


Schreiber KL, Kehlet H, Belfer I, Edwards RR. Predicting, preventing and managing persistent pain after breast cancer surgery: the importance of psychosocial factors. Pain Manag. 2014;4(6):445-59. doi: 10.2217/pmt.14.33


van Helmond N, Timmerman H, van Dasselaar NT, van de Pol CC, Olesen SS, Drewes AM, et al. High body mass index is a potential risk factor for persistent postoperative pain after breast cancer treatment. Pain Physician. 2017;20(5):E661-71. 


Fakhari S, Atashkhoei S, Pourfathi H, Farzin H, Bilehjani E. Postmastectomy pain syndrome. IJWHR. 2017;5(1):18-23. doi 10.15296/ijwhr.2017.04.


Andersen KG, Duriaud HM, Jensen, HE, Kroman N, Kehlet H. Predictive factors for the development of persistent pain after breast cancer surgery. Pain. 2015;156(12):2413-22. doi: 10.1097/j.pain.0000000000000298.


VanDenKerkhof EG, Hopman WM, Goldstein DH, Wilson RA, Towheed TE, Lam M, et al. Impact of perioperative pain intensity, pain qualities, and opioid use on chronic pain after surgery: a prospective cohort study. Reg Anesth Pain Med 2012;37(1):19-27. doi: 10.1097/AAP.0b013e318237516e.


De Oliveira GS Jr, Chang R, Khan SA, Hansen NM, Khan JH, McCarthy RJ, et al. Factors associated with the development of chronic pain after surgery for breast cancer: a prospective cohort from a tertiary center in the United States. Breast J. 2014;20(1):9-14. doi: 10.1111/tbj.12207. 


Kambur O, Kaunisto MA, Tikkanen E, Leal SM, Rippatti S, Kelso EA. Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1000 women undergoing surgery for breast cancer. Anesthesiology. 2013;119(6):1422-33. doi: 10.1097/ALN.0000000000000013.


De Gregori M, Diatchenko L, Belfer I, Allegri M. OPRM1 receptor as new biomarker to help the prediction of post mastectomy pain and recurrence in breast cancer. Minerva Anestesiol. 2015;81(8):894-900. 


Nissenbaum J. From mouse to humans: discovery of the CACNG2 pain susceptibility gene. Clin Genet. 2012:82(4):311-20. doi: 10.1111/j.1399-0004.2012.01924.x.


Habib AS, Kertai MD, Cooter M, Greenup RA, Hwang S. Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study. Reg Anesth Pain Med. 2019;44(2):192-9. doi:10.1136/rapm-2018-000040.


Cho AR, Kwon JY, Kim KH, Lee HJ, Kim HK, Kim ES, et al. The effects of anesthetics on chronic pain after breast cancer surgery. Anesth Analg. 2013;116(3):685-93. doi: 10.1213/ANE.0b013e31827ee372.


Langford DJ, Paul SM, West C, Levine JD, Hamolsky D, Elboim C, et al. Persistent breast pain following breast cancer surgery is associated with persistent sensory changes, pain interference, and functional impairments. J Pain. 2014;15(12):1227-37. doi: 10.1016/j.jpain.2014.08.014.


Steyaert A, Forgot P, Dubois V, Lavand`homme P, De Kock M. Does the perioperative analgesic/anesthetic regimen influence the prevalence of chronic pain after mastectomy. J Clin Anesth. 2016;33;20-5. doi: 10.1016/j.jclinane.2015.07.010.


Cheng GS, Ilfeld BM. An evidence-based review of the efficacy of perioperative analgesic techniques for breast cancer-related surgery. Pain Med. 2017;18(7):1344-56. doi: 10.1093/pm/pnw172.


Larsson IM, Sorensen JA, Bille C. The post-mastectomy pain syndrome- A systematic review of the treatment modalities. Breast J. 2017;23(3):338-43. doi: 10.1111/tbj.12739.



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