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Enfermedad celiaca silente en Dermatología / Silent celiac disease in dermatology
Resumen
Resumen
Introducción: la enfermedad celiaca puede estar asociada en forma silente a varias enfermedades de la piel y mucosas.
Objetivos: determinar la frecuencia de enfermedad celiaca en portadores de urticaria crónica, vitíligo, alopecia areata, psoriasis y estomatitis aftosa del Hospital Nacional (Itauguá, Paraguay) en años 2017 y 2018.
Métodos: se utilizó un diseño observacional de corte transversal, prospectivo. Se realizó la detección del anticuerpo IgA antitransglutaminasa tisular e IgA sérica en pacientes adolescentes y adultos que otorgaron su consentimiento informado. En los casos positivos se realizó la confirmación histológica con biopsias duodenales.
Resultados: fueron incluidos 79 pacientes, con predominio del sexo femenino (75%). La mediana de edad fue 33 años y el índice de masa corporal medio fue 24,7 k/m2. La enfermedad celiaca se demostró histológicamente en 4/32 portadores de estomatitis aftosa, en 2/24 con vitíligo, en 1/17 con alopecía areata. No se detectó en pacientes con urticaria crónica ni psoriasis.
Conclusión: la frecuencia de enfermedad celiaca confirmada histológicamente en pacientes con estomatitis aftosa, vitíligo o alopecía areata fue 8,8%.
Abstract
Background: Silent celiac disease may be associated to various skin and mucous membranes diseases.
Objective: Determine the frequency of celiac disease in carriers of chronic urticaria, vitiligo, alopecia areata, psoriasis and aphthous stomatitis treated in the National Hospital of Itauguá, Paraguay, in years 2017 and 2018.
Material and methods: An observational cross-sectional, prospective design was used. IgA tissue antitransglutaminase antibody and serum IgA was determined in adolescents and adult patients who gave their informed consent. In positive cases, histological confirmation was performed with duodenal biopsies.
Results: 79 patients were included, with a predominance of females (75%). Median age was 33 years, and the average body mass index 24.7 kg/m2. Celiac disease was demonstrated histologically in 4/32 carriers of aphthous stomatitis, in 2/24 with vitiligo, and in 1/17 with alopecia areata. It was not detected in patients with chronic urticaria or psoriasis.
Conclusion: Frequency of celiac disease histologically confirmed in patients with aphthous stomatitis, vitiligo or alopecia areata was 8.8%.
Palabras clave
Referencias
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