Envíe este artículo por correo electrónico (Inicie sesión)
Enviar un correo electrónico al autor/a (Inicie sesión) Open Journal Systems
Enfermedad mamaria benigna y riesgo de cáncer de mama: sobrepeso-obesidad, bioquímica, antropometría / Breast benign disease and breast cancer risk. Overweight-obesity, biochemical, anthropometry
Resumen
Resumen
Introducción: la inflamación, las alteraciones metabólicas y antropométricas del fenómeno sobrepeso-obesidad son factores de riesgo para cáncer de mama (CaM) particularmente en mujeres con enfermedad mamaria benigna proliferativa (EMBP).
Objetivo: describir los niveles de adipocitocinas, alteraciones metabólicas y antropométricas en la EMBP y su papel como estimadores de riesgo para CaM en una población con prevalencia de sobrepeso-obesidad de más del 70%.
Material y métodos: estudio transversal analítico en 27 mujeres con CaM y 27 con EMBP. Se realizó diagnóstico nutricional, antropometría y cálculo del índice cintura-talla (ICT); determinación sérica de adipocitocinas, insulina, glucosa y estimación de HOMA IR. Se calcularon promedio y desviaciones estándar, correlaciones de Pearson y Spearman; Odds Ratio (OR) e intervalos de confianza mediante regresión logística como estimadores de riesgo de CaM. Se consideró significativo un valor de p < 0.05.
Conclusión: un ICT > 0.5 en mujeres mayores de 50 años podría ser un estimador antropométrico de riesgo de CaM en mujeres con EMBP.
Abstract
Background: The immunologic, metabolic and anthropometric disturbances of overweight-obesity phenomena are risk factors to breast cancer (BC), particularly in proliferative benign breast disease women (PBBD).
Objective: To describe the adipocytokine levels, metabolic alteration and anthropometric characteristics in PBBD and its role as risk estimator to BC in a population with high overweight-obesity prevalence.
Material and methods: A cross-sectional study. We realized nutritional diagnosis, anthropometry, and we calculated the waist-height rate (WHR); serum measurement of adipocytokines, insulin and glucose and, HOMA IR determination in 27 PBBD and 27 BC women. We calculated mean, standard deviation, Pearson and Spearman correlation coefficients, Odds Ratio (OR) and confidence intervals through logistic regression as risk estimators of BC; p < 0.05 values were considered significant.
Results: Mean age in the PBBD group was minor than BC group, the humeral diameter was greater in BC group women. We did not find differences in anthropometry or adipocytokine levels; in both groups, the predominant somatotype was the endo-mesomorphic. We found higher insulin levels in BC group and a higher percentage of women with WHR > 0.5 too. The WHR > 0.5 + age over 50 were considered risk estimators to develop breast cancer in PBBD women group.
Conclusion: The WHR >0.5 in women with PBBD over 50 years old could be considered an anthropometric risk estimator to develop BC.
Palabras clave
Referencias
Worsham MJ, Raju U, Lu M, Kapke A, Botttrell A, Cheng J, et al. Risk factors for breast cancer from benign breast disease in a diverse population. Breast Cancer Res Treat. 2009;118(1):1-7. https://doi.org//10.1007/s10549-008-0198-8.
Lundin CP, Mertens F, Rizou H, Idvall I, Georgiou G, Ingvar C, et al. Cytogenetic changes in benign proliferative and nonproliferative lesions of the breast. Cancer Genet Cytogenet. 1998; 107(2):118–20.
Djuric Z, Edwards A, Madan S, Darga L, Ren J, Blake C, et al. Obesity is associated with atypia in breast ductal lavage of women with proliferative breast disease. Cancer Epidemiol. 2009;33(3-4):242-8. https://doi.org//10.1016/j.canep.2009.07.003.
Hillers LE, D’Amato JV, Chamberlin T, Paderta G, Arendt LM. Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion. Neoplasia. 2018;20(11):1161-1174. https://doi.org//10.1016/j. neo.2018.09.004.
Dossus L, Rinaldi S, Biessy C, Hernandez M, Lajous M, Monge A, et al. Circulating leptin and adiponectin, and breast density in premenopausal Mexican women: the Mexican Teachers’ Cohort. Cancer Causes Control. 2017;28(9):939- 946. https://doi.org//10.1007/s10552-017-0917-8.
Han C, Zhang HT, Du L, Liu X, Jing J, Zhao X, et al. Serum levels of leptin, insulin, and lipids in relation to breast cancer in China. Endocrine. 2005;26(1):19-24. https://doi.org//10.1385/ENDO:26:1:019.
Secretaría de Salud. GPC Diagnóstico y tratamiento de la perimenopausia y postmenopausia. México: Instituto Mexicano del Seguro Social; 2013. Disponible en: http:// www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/019_GPC_ClimatyMenop/SS_019_08_EyR.pdf.
Turner RC, Mathews DR, Holman RR, Peto J. Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes. Lancet. 1982;1(8272):596-8. https://doi.org/10.1016/S0140-6736(82)91753-6.
Stewart A, Marfell-Jones M, Olds T, de Ridder JH. International Standards for Anthropometric Assessment. 3era ed. Lower Hutt, Nueva Zelanda: International Society for the Advancement of Kinanthropometry; 2011. 115 p.
Li WC, Chen IC, Chang YC, Loke SS, Wang SH, Hsiao KY. Waist-to-height ratio, waist circumference, and body mass index as indices of cardiometabolic risk among 36,642 Taiwanese adults. Eur J Nutr. 2013 Feb;52(1):57-65. https://doi.org//10.1007/s00394-011-0286-0.
International Agency for Research on Cancer. World Health Organization. Population fact sheets: Mexico [Internet]. Francia: WHO; 2018 [Citado 2018 Noviembre 20. Disponible en: http://gco.iarc.fr/today/fact-sheets-populations?population=484 and sex=2#collapse1.
Oh H, Eliassen AH, Wang M, Smith-Warner SA, Beck AH, Schnitt SJ, et al. Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer. NPJ Breast Cancer. 2016;2. pii: 16032. https://doi. org//10.1038/npjbcancer.2016.32.
McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ. 2000;321(7261):624-8.
Visscher DW, Frank RD, Carter JM, Vierkant RA, Winham SJ, Heinzen EP, et al. Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies. J Natl Cancer Inst. 2017;109(10). https://doi.org//10.1093/jnci/djx035.
World Health Organization (WHO). Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Ginebra, Suiza: WHO; 2013. [Fecha de consulta:19 de noviembre de 2018]: [103 p]. Disponible en: h t t p : / / a p p s . w h o . i n t / i r i s / b i t s t r e a m / 1 0 6 6 5 / 94384/1/9789241506236_eng.pdf?ua=1.
Gutiérrez JP, Rivera-Dommarco JA, Shamah-Levy T, Villalpando-Hernández S, Franco A, Cuevas-Nasu L, et al. Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales. [Internet]. Instituto Nacional de Salud Publica. 2013. Disponible en: http://ensanut.insp. mx/informes/ENSANUT2012ResultadosNacionales.pdf.
Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res. 2004;19(4):546-51.
Solis-Trapala I, Schoenmakers I, Goldberg GR, Prentice A, Ward KA. Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women. J Nutr. 2016 Mar 9. pii: jn224485. https://doi.org/10.3945/jn.115.224485.
Sun X, Casbas-Hernandez P, Bigelow C, Makowski L, Joseph Jerry D, Smith Schneider S, et al. Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Breast Cancer Res Treat. 2012;131(3):1003-12. https:// doi.org//10.1007/s10549-011-1789-3.
García-Jiménez C, García-Martínez JM, Chocarro-Calvo A, De la Vieja A. A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose. J Mol Endocrinol. 2013;52(1):R51-66. https:// doi.org//10.1530/JME-13-0152.
Ali AS, Ali S, Ahmad A, Bao B, Philip PA, Sarkar FH. Expression of microRNAs: potential molecular link between obesity, diabetes and cancer. Obes Rev. 2011;12(12):1050- 62. doi: 10.1111/j.1467-789X.2011.00906.x.
Coller HA. Is cancer a metabolic disease? Am J Pathol. 2014;184(1):4-17. https://doi.org/10.1016/j.ajpath.2013.07.035.
Argilés JM, Busquets S, Stemmler B, López-Soriano FJ. Cancer cachexia: understanding the molecular basis. Nat Rev Cancer. 2014;14(11):754-62. https://doi.org/10.1038/nrc3829.
Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros CS, et al. Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab. 2007;92(4):1510-6.
Posso M, Corominas JM, Serrano L, Román M, Torá-Rocamora I, Domingo L, et al; BELE Study Group. Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study. Cancer Med. 2017;6(6):1482-1489. https://doi.org/10.1002/ cam4.1080.
Newman LA, Stark A, Chitale D, Pepe M, Longton G, Worsham MJ, et al. Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer. JAMA Oncol. 2017; 3(8):1102-1106. DOI: https://doi. org/10.1001/jamaoncol.2016.5598.
Key TJ, Appleby PN, Reeves GK, Travis RC, Brinton LA, Helzlsouer KJ, et al; Endogenous Hormones and Breast Cancer Collaborative Group. Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies. Steroids. 2015;99(PtA):49- 55. https://doi.org/10.1016/j.steroids.2014.09.001.
Cintolo-Gonzalez JA, Braun D2, Blackford AL, Mazzola E, Acar A, Plichta JK, et al. Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications. Breast Cancer Res Treat. 2017;164(2):263- 284 DOI: https://doi.org/10.1007/s10549-017-4247-z.
Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A. Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. Endocr J. 2017;64(4):393-401. https://doi.org/10.1507/endocrj.EJ16-0448.
DOI: https://doi.org/10.24875/RMIMSS.M21000110
Enlaces refback
- No hay ningún enlace refback.