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Enfermedad mamaria benigna y riesgo de cáncer de mama: sobrepeso-obesidad, bioquímica, antropometría

Luis Aarón Quiroga-Morales, Daniel Sat-Muñoz, Brenda Eugenia Martínez-Herrera, Jorge Luis Ramírez-Pineda, Caridad Aurea Leal-Cortés, Eliseo Portilla-de-Buen, Benjamín Trujillo-Hernández, Mario Salazar-Páramo, Luz Ma. Adriana Balderas-Peña

Resumen


Introducción: la inflamación, las alteraciones metabólicas y antropométricas del fenómeno sobrepeso-obesidad son factores de riesgo para cáncer de mama (CaM) particularmente en mujeres con enfermedad mamaria benigna proliferativa (EMBP).

Objetivo: describir los niveles de adipocitocinas, alteraciones metabólicas y antropométricas en la EMBP y su papel como estimadores de riesgo para CaM en una población con prevalencia de sobrepeso-obesidad de más del 70%.

Material y métodos: estudio transversal analítico en 27 mujeres con CaM y 27 con EMBP. Se realizó diagnóstico nutricional, antropometría y cálculo del índice cintura-talla (ICT); determinación sérica de adipocitocinas, insulina, glucosa y estimación de HOMA IR. Se calcularon promedio y desviaciones estándar, correlaciones de Pearson y Spearman; Odds Ratio (OR) e intervalos de confianza mediante regresión logística como estimadores de riesgo de CaM. Se consideró significativo un valor de p < 0.05.

Conclusión: un ICT > 0.5 en mujeres mayores de 50 años podría ser un estimador antropométrico de riesgo de CaM en mujeres con EMBP.


Palabras clave


Obesidad; Enfermedades de la Mama; Síndrome Metabólico; Adipoquinas; Antropometría

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DOI: https://doi.org/10.24875/RMIMSS.M21000110

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