Resumen
En relación con el artículo “Isquemia retiniana como marcador temprano de insuficiencia renal en retinopatía no proliferativa” de Muñoz-Cornejo et al., la isquemia retiniana refleja daño microvascular, la hiperglucemia causa daño endotelial, oclusión vascular y liberación de factores proangiogénicos, lo cual está vinculado con la presencia de retinopatía y nefropatía. Sin embargo, el estudio tiene limitaciones: usa terminología desactualizada, no evalúa marcadores renales clave ni controla factores confusores. Aunque 25 (45%) de los pacientes con isquemia retiniana tenían albuminuria, no se probó correlación con el deterioro renal, y el daño renal podría preceder al ocular. Se requieren parámetros más precisos para establecer esta asociación.
Abstract
Regarding the article “Retinal ischemia as an early marker of renal failure in non-proliferative retinopathy” by Muñoz-Cornejo et al., retinal ischemia reflects microvascular damage, hyperglycemia causes endothelial damage, vascular occlusion, and the release of proangiogenic factors, which is linked with the presence of retinopathy and nephropathy. However, the study has limitations: it uses outdated terminology, it does not evaluate key renal markers, and it does not control for confounding factors. Although 25 (45%) of the patients with retinal ischemia had albuminuria, no correlation with renal deterioration was proven, and renal damage could precede ocular damage. More precise parameters are needed to establish this association.
Muñoz-Cornejo A, Trujillo-Sánchez GP, López-Montero LM, et al. Isquemia retiniana como marcador temprano de insuficiencia renal en retinopatía no proliferativa. Rev Med Inst Mex Seguro Soc. 2025;63(2):e6434. doi: 10.5281/zenodo.14617022
Grønbæk H, Nielsen B, Frystyk J, et al. Effect of octreotide on experimental diabetic renal and glomerular growth: importance of early intervention. Journal Of Endocrinology. 1995;147(1):95-102. doi: 10.1677/joe.0.1470095
ElSayed NA, Aleppo G, Bannuru RR, et al. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes. 2024 Crossref. doi: 10.2337/dc24-S011
Umanath K, Lewis JB. Update on Diabetic Nephropathy: Core Curriculum 2018. Am J Kidney Dis. 2018;71(6):884-95. doi: 10.1053/j.ajkd.2017.10.026
Stevens PE, Ahmed SB, Carrero JJ, et al. A Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-314. doi: 10.1016/j.kint.2023.10.018
Gelcho GN, Gari FS. Time to Diabetic Retinopathy and Its Risk Factors among Diabetes Mellitus Patients in Jimma University Medical Center, Jimma, Southwest Ethiopia. Ethiopian Journal of Health Sciences. 2022;32(5):937-46. doi: 10.4314/ejhs.v32i5.9
Fung TH, Patel B, Wilmot EG, et al. Diabetic retinopathy for the non-ophthalmologist. Clinical Medicine. 2022;22(2):112-6. doi: 10.7861/clinmed.2021-0792