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Asociación de vitamina D sérica y disfunción aguda del injerto renal / Association of serum vitamin D and acute renal graft dysfunction
Resumen
Resumen
Introducción: la enfermedad renal crónica (ERC) es una entidad clínica caracterizada por el deterioro definitivo o no reversible de la arquitectura del riñón o de su estado funcional. El trasplante renal es el tratamiento de elección para la ERC. Nuevas terapias farmacológicas se han investigado con la finalidad de disminuir el riesgo de rechazo de injerto renal; un ejemplo de ello es la vitamina D. Sin embargo, la evidencia internacional presenta resultados mixtos.
Objetivo: evaluar la relación entre los niveles séricos de vitamina D y la prevalencia de disfunción aguda del injerto renal en pacientes que recibieron trasplante renal.
Material y métodos: se llevó a cabo un estudio retrospectivo, observacional y comparativo que tuvo como población a pacientes sometidos a trasplante renal. Se integraron 30 pacientes que fueron clasificados en 2 grupos: grupo 1: los pacientes con disfunción aguda del injerto y grupo 2, aquellos sin disfunción aguda del injerto.
Resultados: se encontró una relación estadísticamente significativa entre la disfunción aguda del injerto renal y los niveles séricos de vitamina D (p = 0.003). El resto de las características no mostraron una relación estadísticamente significativa con la disfunción aguda del injerto renal.
Conclusiones: los niveles bajos de 25-hidroxivitamina D mostraron una asociación estadísticamente significativa con la disfunción aguda del injerto renal.
Abstract
Background: Chronic kidney disease (CKD) is a clinical entity characterized by definitive or non-reversible deterioration of the kidney’s architecture and/or its functional status. Renal transplantation is the treatment of choice for CKD. New pharmacological therapies have been investigated with the aim of reducing the risk of renal graft rejection; an example of this is vitamin D. However, international evidence presents mixed results.
Objective: To evaluate the relationship between serum vitamin D levels and the prevalence of acute renal graft dysfunction in renal transplant patients.
Material and methods: A prospective, observational and comparative study was carried out with a population of patients who underwent renal transplantation. The patients were classified into 2 groups: group 1: patients with acute graft dysfunction, and group 2, those without acute graft dysfunction.
Results: A statistically significant relationship was found between acute renal graft dysfunction and serum vitamin D levels (p = 0.003). All other characteristics did not show a statistically significant relationship with acute renal graft dysfunction.
Conclusions: Low 25-hydroxyvitamin D levels showed a statistically significant association with acute renal graft dysfunction.
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Ammirati AL. Chronic kidney disease. Rev Assoc Med Bras. 2020;66(Suppl1):S3-9.
García-Maset R, Bover J, Segura de la Morena J, et al. Documento de información y consenso para la detección y manejo de la enfermedad renal crónica. Nefrología. 2022;42(3):233-64.
Agudelo-Botero M, Valdez-Ortiz R, Giraldo-Rodríguez L, et al. Overview of the burden of chronic kidney disease in Mexico: Secondary data analysis based on the Global Burden of Disease Study 2017. BMJ Open. 2020;10(3).
Kramer H. Diet and Chronic Kidney Disease. Adv Nutr. 2019;10(Suppl_4):S367-S379. doi: 10.1093/advances/nmz011
Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol. 2020;16(5):251. doi: 10.1038/s41581-020-0268-7
Vasquez-Jimenez E, Madero M. Global Dialysis Perspective: Mexico. Kidney360. 2020;1(6):534-537. doi: 10.34067/KID.0000912020
Tang Z, Yu S, Pan Y. The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies. J Transl Med. 2023;21(1):689. doi: 10.1186/s12967-023-04455-2
Johnson RJ, Sánchez-Lozada LG, Newman LS, et al. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. doi: 10.1159/000500344
Sawinski D, Poggio ED. Introduction to Kidney Transplantation: Long-Term Management Challenges. Clin J Am Soc Nephrol. 2021;16(8):1262-3. doi: 10.2215/CJN.13440820
Hariharan S, Israni AK, Danovitch G. Long-Term Survival after Kidney Transplantation. N Engl J Med. 2021;385(8):729-743. doi: 10.1056/NEJMra2014530
Ahmadpoor P, Ilkhanizadeh B, Ghasemmahdi L, et al. Effect of active vitamin D on expression of co-stimulatory molecules and HLA-DR in renal transplant recipients. Exp Clin Transplant. 2009;7(2):99-103.
Messa P, Regalia A, Alfieri CM. Nutritional vitamin D in renal transplant patients: Speculations and reality. Nutrients. 2017;9(6). doi: 10.3390/nu9060550
Awadain WH, Mohamad EM, Almessallamy FA, et al. Prevalence of Hypovitaminosis D among Renal Transplant Recipients and Its Relation to Graft Interstitial Fibrosis. Zagazig University Medical Journal. 2019;25(5):748-58. Disponible en: https://zumj.journals.ekb.eg/article_46487_ec841f948443bfdbd0ee016336805e19.pdf
B Argentino AC, Souza JF, Dos Santos Sens YA. Evaluation of the anthropometric clinical measurements and Vitamin D status in kidney transplant recipients: Comparison between sexes. Saudi J Kidney Dis Transpl. 2019;30(1):24-32
Buyukdemirci S, Oguz EG, Cimen SG, et al. Vitamin D deficiency may predispose patients to increased risk of kidney transplant rejection. World J Transplant. 2022;12(9):299-309. doi: 10.5500/wjt.v12.i9.299
Mehrotra S, Sharma RK, Gupta A, et al. Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients. J Renal Inj Prev. 2018;7(4):224-9.
Hesketh CC, Knoll GA, Molnar AO, et al. Vitamin D and kidney transplant outcomes: a protocol for a systematic review and meta-analysis. Syst Rev. 2014;3:64. doi: 10.1186/2046-4053-3-64
Filipov JJ, Dimitrov EP. Vitamin D After Kidney Transplantation: Metabolism and Clinical Importance. EMJ Nephrol. 2017;5(1):75-82. doi: 10.33590/emjnephrol/10311600
Astor BC, Djamali A, Mandelbrot DA, et al. The association of 25-hydroxyvitamin D levels with late Cytomegalovirus infection in kidney transplant recipients: The Wisconsin allograft recipient database: The Wisconsin allograft recipient database. Transplantation. 2019;103(8):1683-8. doi: 10.1097/TP.0000000000002672
Regalia A, Benedetti M, Malvica S, et al. Vitamin D status and SARS-CoV-2 infection in a cohort of kidney transplanted patients. Nutrients. 2022;14(2):317. doi: 10.3390/nu14020317
Messa P, Castellano G, Vettoretti S, et al. Vitamin D and calcium supplementation and urolithiasis: A controversial and multifaceted relationship. Nutrients. 2023;15(7):1724. doi: 10.3390/nu15071724
Bargagli M, Ferraro PM, Vittori M, et al. Calcium and vitamin D supplementation and their association with kidney stone disease: A narrative review. Nutrients. 2021;13(12):4363. doi: 10.3390/nu13124363
Quach K, Abdelmasih M, Chen PX, et al. Vitamin D levels and the risk of posttransplant diabetes mellitus after kidney transplantation. Prog Transplant. 2021;31(2):133-41. doi: 10.1177/15269248211002796
Courbebaisse M, Bourmaud A, Souberbielle JC, et al. Nonskeletal and skeletal effects of high doses versus low doses of vitamin D3 in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial. Am J Transplant. 2023;23(3):366-76. doi: 10.1016/j.ajt.2022.12.007
DOI: https://doi.org/10.24875/10.5281/zenodo.15178453
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