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El uso de biomarcadores en cáncer de mama

María Teresa de Jesús Cervantes-Díaz, Patricia Piña-Sánchez, Yelda Aurora Leal-Herrera

Resumen


Los avances en el entendimiento de la biología molecular del cáncer han permitido que en los últimos 30 años algunos biomarcadores en cáncer hayan logrado ser trasladados del laboratorio a la práctica clínica y se hayan ido estableciendo como herramientas sumamente importantes en el manejo de las pacientes con cáncer de mama. En esta revisión se presentan algunos biomarcadores de uso rutinario en la práctica clínica oncológica que tienen un valor clínico bien establecido para dirigir el tratamiento y establecer el pronóstico en pacientes con cáncer de mama, como el ER-alfa (receptor de estrógenos alfa), el PR (receptor de progesterona), el HER2 (receptor 2 del factor de crecimiento epidérmico humano), el Ki-67 (marcador de proliferación Ki-67) y otros biomarcadores, como las firmas multigénicas, las cuales son usadas cada vez con más frecuencia, debido al valor clínico mostrado en diversos ensayos clínicos aleatorizados y por ser cada vez más accesibles en la práctica clínica diaria. Dada la considerable importancia del cáncer de mama en la salud pública, es necesario estar actualizados con respecto a estos biomarcadores de uso clínico, los cuales nos pueden permitir brindarles a las pacientes un tratamiento más personalizado, así como conocer su pronóstico.


Palabras clave


Biomarcadores; Biomarcadores de Tumor; Neoplasias de la Mama.

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DOI: https://doi.org/10.24875/RMIMSS.M20000118

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