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Síndrome de respuesta inflamatoria multisistémica asociado a COVID-19 en población pediátrica / Multisystem inflammatory syndrome associated to COVID-19 in pediatric population
Resumen
Resumen
El nuevo coronavirus SARS-CoV-2 parece tener una menor agresividad sobre la población pediátrica en comparación con la adulta. Sin embargo, más recientemente, al incrementar el número de pacientes pediátricos diagnosticados se ha podido observar el desarrollo de un síndrome de respuesta inflamatoria multisistémica potencialmente asociado a COVID 19 en niños. Nuestro objetivo fue recuperar y sintetizar los reportes que han descrito el síndrome de respuesta inflamatoria multisistémica potencialmente asociado a COVID 19 en niños. Se realizó un estudio de revisión de tipo narrativo de la literatura científica publicada en PubMed desde el 1 de enero 2020 al 30 de junio 2020. Los términos de búsqueda fueron síndrome inflamatorio multisistémico, Kawasaki, niños, COVID-19. El nuevo síndrome se ha asociado con una mayor dificultad para tratar a los niños con COVID-19 y se han observado algunas muertes secundarias a ello. Pero por el otro lado, la inmunidad innata pediátrica, dada por IgM, y la rápida respuesta para generar células de memoria dependientes y no dependientes del centro germinal se hipotetiza por algunos autores que podría explicar en gran parte el comportamiento y la incidencia de la nueva infección por SARS-CoV-2.
Abstract
The new SARS-CoV-2 coronavirus appears to be less aggressive in the pediatric population in comparison to the adult population. Yet, most recently, as the number of diagnosed pediatric patients with COVID-19 has increased, clinicians have observed the development of a multisystemic inflammatory response syndrome that is potentially associated with COVID-19 in the pediatric population. Our objective was to retrieve and synthesize the reports that have described the multisystemic inflammatory response syndrome potentially associated with COVID-19 in the pediatric population. We conducted a narrative review of scientific literature reported in PubMed from January 1st to June 30th, 2020, with the terms multisystem inflammatory syndrome, Kawasaki, children, COVID-19. This new syndrome has been associated with greater difficulty in treating children with COVID-19 and some deaths have been observed as a result. On the other hand, innate pediatric immunity, primarily driven by IgM, and the rapid immune response to generate germ-center dependent and non-dependent memory B cells as it has been hypothesized for other authors could largely explain the behavior and incidence of the new SARS-CoV-2 infection in the pediatric population.
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Referencias
Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, McKiernan CA et al. Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. 2020 May 11. doi: 10.1001/jamapediatrics.2020.1948.
Lu X, Zhang L, Du H, Zhang J, Li YY, Qu, J et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663-1665. doi: 10.1056/NEJMc2005073.
Carsetti R. Quintarelli C. Quinti I, Piano Mortari E, Zumla A, Ippolito G, et al. The immune system of children: the key to understanding SARS-CoV-2 susceptibility? The Lancet Child Adolesc Health 2020. https://doi.org/10.1016/ S2352-4642(20)30135-8.
Lindsey B, Kampmann B, Jones C. Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants. Curr Opin Infect Dis. 2013;26(3):248-53. doi: 10.1097/QCO.0b013e3283607a58.
Lam JH, Smith FL, Baumgarth N. B Cell Activation and Response Regulation During Viral Infections. Viral Immunol. 2020 Apr 23. doi: 10.1089/vim.2019.020
New York State Department of Health. Health advisory: pediatric multi-system inflammatory syndrome potentially associated with coronavirus disease (COVID-19) New York State Department of Health [consultado el 13 de mayo de 2020]; 6 de mayo de 2020. Disponible en: http://dmna.ny.gov/covid19/docs/all/DOH_COVID19_PediatricInflammatorySyndrome_050620.pdf
Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. doi:10.1136/bmj.m2094
Moreira A. Kawasaki disease linked to COVID-19 in children [published online ahead of print, 2020 May 27]. Nat Rev Immunol. 2020;1. doi:10.1038/s41577-020-0350-1
Alizargar J. The novel coronavirus (COVID-19) and the risk of Kawasaki disease in children [published online ahead of print, 2020 May 23]. J Formos Med Assoc. 2020;S0929-6646(20)30220-5. doi: 10.1016/j.jfma.2020.05.030
Russo M. NY Children Sick With Rare COVID-Related Illness, State Finds; Here Are the Warning Signs. NBC New York [Internet] 05 14 2020 [consultado el 13 de mayo de 2020]. Disponible en: https://www.nbcnewyork.com/news/local/15-nyc-children-sickened-with-rare-covid-related-illness-here-are-the-warning-signs/2404162/
Guidance: Paediatric multisystem in ammatory syndrome temporally associated with COVID-19. May 2020 Royal College of Paediatrics and Child Health (RCPCH) United Kingdom.
Kanthimathinathan HK, Dhesi A, Hartshorn S, Ali SH, Kirk J, Nagakumar P, et al. COVID-19: A UK Children's Hospital Experience. Hosp Pediatr. 2020;hpeds.2020-000208. doi: 10.1542/hpeds.2020-000208
Khan EA. COVID-19 in children: Epidemiology, presentation, diagnosis and management. J Pak Med Assoc. 2020;70(Suppl 3)(5):S108‐S112. doi: 10.5455/JPMA.25
Panupattanapong S, Brooks EB. New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response. Cleve Clin J Med. 2020;10.3949/ccjm.87a.ccc039. doi:10.3949/ccjm.87a.ccc039
Teresa RH, Michelle DP, Mark DH. COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach. Progress in Pediatric Cardiology. 2020;101232:1-24.
Oualha M, Bendavid M, Berteloot L, Corsia A, Lesage F, Vedrenne M et al. Severe and fatal forms of COVID-19 in children. Arch Pediatr. 2020;S0929-693X(20)30117-2. doi:10.1016/j.arcped.2020.05.010
Grimaud M, Starck J, Levy M, Marais C, Chareyre J, Khraiche D, et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann Intensive Care. 2020;10(1):69. Published 2020 Jun 1. doi: 10.1186/s13613-020-00690-8
Fliesler N. COVID-19 and a serious inflammatory syndrome in children: Unpacking recent warnings. Clinical Care, Specialty Care. Boston Children Hospital. Disponible en: https://discoveries.childrenshospital.org/covid-19-inflammatory-syndrome-children/
Blondiaux E, Parisot P, Redheuil A, Tzaroukian L, Levy Y, Sileo C, et al. Cardiac MRI in Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series. Radiology. 2020;202288. doi: 10.1148/radiol.2020202288
Xu S, Chen M, Weng J. COVID-19 and Kawasaki disease in children. Pharmacol Res. 2020;159:104951. doi: 10.1016/j.phrs.2020.104951
Calabri GB, Formigari R. Covid-19 and Kawasaki Disease: A Glimpse at the Past for a Predictable Future. Pediatr Cardiol. 2020;1. doi:10.1007/s00246-020-02385-0
Rauf A, Vijayan A, John ST, Krishnan R, Latheef A. Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during COVID-19 Pandemic. Indian J Pediatr. 2020;10.1007/s12098-020-03357-1. doi: 10.1007/s12098-020-03357-1
Ronconi G, Teté G, Kritas SK, Gallenga CE, Caraffa A, Ross R, et al. SARS-CoV-2, which induces COVID-19, causes kawasaki-like disease in children: role of pro-inflammatory and anti-inflammatory cytokines. J Biol Regul Homeost Agents. 2020;34(3):10.23812
Wensveen FM, Valentić S, Šestan M, Wensveen TT, Polić B. Interactions between adipose tissue and the immune system in health and malnutrition. Semin Immunol. 2015 Sep;27(5):322-33. doi: 10.1016/j.smim.2015.10.006.
Peron JPS, Nakaya H. Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). Clinics (Sao Paulo). 2020;75:e1912. doi: 10.6061/clinics/2020/e1912
Ebmeier S, Cunnington AJ. Correspondence regarding recently published editorial: 'Will children reveal their secret? The coronavirus dilemma'. Eur Respir J. 2020;2001601. doi: 10.1183/13993003.01601-2020
Radzikowska U, Ding M, Tan G, Zhakparov D, Peng Y, Wawrzyniak P, et al. Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors. Allergy. 2020;10.1111/all.14429. doi:10.1111/all.14429
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