Evaluation of a rapid immunological test for tuberculosis diagnosis
Main Article Content
Keywords
Tuberculosis, pulmonary, Immunologic test, Chromatography
Abstract
Objective: to evaluate a Mexican rapid immunologic test (PRIM) for pulmonary tuberculosis (PTB).
Methods: a diagnostic test was evaluated at the National Institute of Respiratory Diseases in Mexico City. Class 3 of the American Thorax Society (ATS) for tuberculosis (TB) was considered for PTB. Physical examination, sputum smear, chest X-ray and PRIM were performed to all participants.
Results: a total of 143 patients were included (mean age was 41 years). Seventy two patients were classified as PTB and 71 as latent TB infection (LTBI) or healthy. The sensibility of the rapid immunologic test (RIT) was 79.2 % (CI 95 % = 67.2-87.5), the specificity 100 % (CI 95 % = 93.6-100), Positive predictive value (PV) 100 % (CI 95 % = 92.1-100) and negative PV 82.6 % (CI 95 % = 72.5-89.6). The positive likelihood ratio was 563 (CI 95 % = 1.15-4000.6).
Conclusions: the RIT showed a high sensibility and specificity. Results demonstrate the potential of the RIT for identifying patients with active pulmonary TB.
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