The searching discover of statins and the Lasker prize

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Arturo Zárate
<p>Instituto Mexicano del Seguro Social, Centro M&eacute;dico Nacional Siglo XXI, Unidad de Investigaci&oacute;n de Endocrinolog&iacute;a.&nbsp;Distrito Federal</p>

Lourdes Basurto
<p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Unidad de Investigaci&oacute;n de Endocrinolog&iacute;a.&nbsp;Distrito Federal</p>

Renata Saucedo
<p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Unidad de Investigaci&oacute;n de Endocrinolog&iacute;a.&nbsp;Distrito Federal</p>

Keywords

Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cholesterol, Atherosclerosis

Abstract

Akira Endo identified a cholesterol-lowering substance that antagonized HMG-CoA reductase, decreasing cholesterol biosynthesis. These studies led to the development of statin, which was efficient to decrease cholesterol levels in blood in order to prevent atherosclerosis and cardiovascular disease.

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References

Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Cholesterol Treatment Trialists’ (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 2005; 366(9493):1267-1278.

 

Shanes JG, Minadeo KN, Moret A, Groner M. Statin therapy in heart failure: prognostic effects and potential mechanisms. Am Heart J 2007;154:617-623.

 

Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, et al. Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 (PROVE IT-TIMI 22) investigators. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005;352(1):20-28.

 

Calabro P, Yeh ET. The pleiotropic effects of statins. Curr Opin Cardiol 2005;20(6):541-546.

 

Tobert JA. Lovastatin y más allá: la historia de los inhibidores de HMG-CoA reductasa. Nat Rev Drug Discov 2003; 2 (7): 517-526.

 

Goldstein JL, Brown MS. La vía de las lipoproteínas de baja densidad y su relación con la aterosclerosis. Annu Rev Biochem 1977; 46: 897-930.

 

Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al. Grupo de estudio JUPITER. Rosuvastatin para prevenir eventos vasculares en hombres y mujeres con proteína C-reactiva elevada. N Engl J Med 2008; 359 (21): 2195-207.

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PDF (Spanish)
Published
March 2, 2021
Issue
Vol. 47 No. 2 (2009): March-April
Section
Editorial

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How to Cite

1.
Zárate A, Basurto L, Saucedo R. The searching discover of statins and the Lasker prize. Rev Med Inst Mex Seguro Soc [Internet]. 2021 Mar. 2 [cited 2025 Jul. 16];47(2):119-20. Available from: https://revistamedica.imss.gob.mx/index.php/revista_medica/article/view/1826