CXCL5 en el tracto respiratorio superior de niños con influenza A
Main Article Content
Keywords
Influenza humana, Subtipo H1N1 del virus de la influenza A, Neutrófilos, Quimiocinas
Abstract
Introducción: la infiltración por neutrófilos es una característica importante en la patogenia de la infección por influenza. Los factores que regulan la afluencia de neutrófilos no están completamente establecidos. Nuestro objetivo fue estudiar la liberación de CXCL5 , potente quimioatrayente de neutrófilos, en niños con influenza naturalmente adquirida.
Métodos: la concentración de CXCL5 fue investigada mediante ensayo inmunoenzimático en aspirados nasales de niños (n = 18) con síntomas respiratorios desencadenados predominantemente por el virus de la influenza A.
Resultados: se encontró incremento en los niveles de CXCL5 en aspirados nasales obtenidos cuando los niños presentaban síntomas respiratorios, comparados con muestras de los mismos niños obtenidas después de cuatro semanas sin síntomas (medianas 1850 pg/mL adversus 30 pg/mL, p < 0.005). CXCL5 fue purificada de las muestras y se demostró actividad biológica quimiotáctica para neutrófilos.
Conclusiones: se sugiere un papel importante para CXCL5 en la atracción de neutrófilos a las vías aéreas superiores en infección respiratoria desencadenada por virus de la influenza, y podría ser un blanco para la intervención terapéutica.
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