Thin layer chromatography and infrared spectroscopy in the diagnosis of salicylic intoxication
Main Article Content
Keywords
Salicylates, Chromatography, Spectrometry, Toxicology
Abstract
Drugs are the main causal agents in intoxications with suicide purposes. Salicylates are few frequency related. In this paper we reported a patient with suspicion of acute exogenous intoxication with salicylates. The patient showed clinical symptoms of fever, hypoglycaemia, low cardiac rhythm, hyperventilation, pulmonary edema and coma. We employed analytical toxicology to elucidate the drug involved in the intoxication, using thin layer chromatography (TLC) and infrared spectrometry to detect acetyl salicylic acid, as the cause agent of intoxication clinical pattern, in acids extracts from urine and gastric content. The analytical results corresponds with clinical symptom showed by patient and the information obtained with the medical monitoring of him.
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