Nutritional indicators in children in children with acute lymphoblastic leukemia

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Martha I. Dávila-Rodríguez
Hilda I. Novelo-Huerta
Rafael Márquez-Solís
Elva I. Cortés- Gutiérrez
Patricia Pérez-Cortés
Ricardo M. Cerda-Flores

Keywords

Acute Lymphoblastic Leukemia, Child nutrition, Child

Abstract

Background: a nutritional assessment allows to determine the state of nutrition and to predict the possibility of displaying additional risks for a disease. Previous investigations have verified that it is not sufficient for children with acute lymphoblastic leukemia (ALL) to have registry of anthropometric measurements such as age, weight, and height. Given the previous information, it is necessary to conduct studies with nutritional indicators that contribute to understanding their importance in children with ALL.

Objective: to compare the nutritional values of five indicators of children with and without ALL. 

Methods: a sample of 21 children with a diagnosis of ALL and 54 children without ALL (control) participated in the study; the children’s ages ranged between 1.3 to 10 years. Comparisons between cases and controls were performed.

Results: indicators of albumin and triceps skin fold showed differences between the groups (p < 0.005). 

Conclusions: children with ALL at time of diagnosis had nutritional deficiencies of subcutaneous fat reserve  and protein. These indicators could be part of the prognostic and standard of care for children with this cancer.

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References

Sharp L, Cotton S, Little J. Descriptive epidemiology. En: Little J, editor. Epidemiology of childhood cancer. Lyon, France: IARC Scientific Publication; 1999. p. 10-66. 

 

Juárez-Ocaña S, González-Miranda G, Mejía-Aranguré JM, Rendón-Macías ME, Martínez-García MC, Fajardo-Gutiérrez A. Frequency of cancer in children residing in Mexico City and treated in the hospitals of the Instituto Mexicano del Seguro Social (1996-2001). BMC Cancer. 2004; 4:50. Disponible en http://www. biomedcentral.com/1471-2407/4/50

 

Mejía-Aranguré JM, Bonilla M, Lorenzana R, Juárez-Ocaña S, de Reyes G, Pérez-Saldívar ML, et al. Incidence of leukemias in children from El Salvador and Mexico City between 1996 and 2000: population-based data. BMC Cancer. 2005; 5:33. Disponible en http://www. biomedcentral.com/1471-2407/5/33

 

Viana MB, Fernández RA, de Olvera BM, Murao M, de Andrade-Paes C, Duarte AA. Nutricional and socioeconomic status in the prognosis of childhood acute lymphoblastic leukemia. Haematologica. 2001; 86 (2):113-120.

 

Isselbacher KJ, Braunwald E, Wilson J, Martin JB, Fauci AS, et al. Harrison´s. Principios de medicina interna. Vol. II. Tercera edición. México: McGraw-Hill-Interamericana; 1994. p. 2030.

 

Lobato-Mendizábal E, Ruiz-Argüelles GJ, Marín-López A. Leukemia and nutrition. I. Malnutrition is an adverse prognostic factor in the outcome of treatment with standard risk acute lympho-blastic leukemia. Leuk Res. 1989; 13 (10):899-906.

 

Tazi I, Hidane Z, Zafad S, Harif M, Benchekroun S, Ribeiro R. Nutritional status at diagnosis of children with malignancies in Casablanca. Pediatr Blood Cancer. 2008; 51 (4):495-498.

 

Salas-Salvado J, Bonada A, Trallero R, Salò ME. Nutrición y dietética clínica. Segunda edición. Barcelona, España: Masson; 2000. 

 

Marín-López A, Lobato-Mendizábal E, Ruiz-Argüelles GJ. Malnutrition is an adverse prognostic factor in the response to treatment and survival of patients with acute lymphoblastic leukemia at the usual risk. Gac Med Mex. 1991; 127 (2):125-131.

 

Weir J, Reilly JJ, Mc Coll JH, Gibson BE. No evidence for an effect of nutritional status at diagnosis on prognosis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 1998; 20 (6):534-538.

 

Guo SW, Thompson EA. Technical Report No. 187. Departmental of Statistics, Washington: University of Washington; 1989.

 

Lobato-Mendizábal E, López-Martínez B, Ruiz-Argüelles GJ, A clinical review of the prognostic value of the nutritional status at diagnosis in the outcome of therapy of children with acute lymphoblastic leukemia. Rev Invest Clin. 2003; 55 (1):31-35.  

 

Yu LC, Kuvibidila S, Ducos R, Warrier RP. Nutritional status of children with leukemia. Med Pediatr Oncol. 1994; 22 (2):73-77.

 

Gibson RS. Principles of nutritional assessment. New York: Oxford: University Press; 1990. 

 

Calzada-de León R. Crecimiento del niño sano. México: McGraw-Hill-Interamericana; 1998. p. 8-10.

 

González A, Cortina L, González P, González C, García T, de Svarch EG. Longitudinal assessment of nutritional status in children treated for acute lymphoblastic leukaemia in Cuba. Eur J Cancer. 2004; 40 (7):1031-1032.

 

Antillon F, de Maselli T, Garcia T, Rossi E, Sala A. Nutritional status of children during treatment for acute lymphoblastic leukemia in the Central American Pediatric Hematology Oncology Association (AHOPCA): preliminary data from Guatemala. Pediatr Blood Cancer. 2008; 50 (2 Suppl):502-505.

 

Eston RG, Rowlands AV, Charlesworth S, Davies A, Hoppitt T. Prediction of DXA-determined whole body fat from skinfolds: importance of including skinfolds from the thigh and calf in young, healthy men and women. Eur J Clin Nutr. 2005; 59 (5):695-702.

 

Numeroso F, Barilli AL, Delsignore R. Prevalence and significance of hypoalbuminemia in an internal medicine department. Eur J Intern Med. 2008; 19 (8):587-591. 

 

Levis A, Ficara F, Marmont F, De Crescenzo A, Resegotti L. Prognostic significance of serum albumin in chronic lymphocytic leukemia. Haematologica .1991; 76(2):113-119.

 

Koskelo EK, Saarinen UM, Siimes MA. Low levels of serum transport proteins indicate catabolic protein status during induction therapy for acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1991; 8 (1):53-59.

 

Kurugöl Z, Egemen A, Cetingül N, Kavakli K, NiSli G, Oztop S. Nutritional status of children with leukemia. Med Pediatr Oncol. 1997; 28 (4):321-322. 

 

Drup R, Hernández A, Pollono D. Incidence of childhood cancer in La Plata, Argentina, 1977-1987. Int J Cancer. 1990; 45 (6):1045-1047.

 

Frisancho AR. New norms to upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nut 1981; 34 (11):2540-2445.