Dermatoglyphics differences among children with nephrotic syndrome according to steroid response
Main Article Content
Keywords
Dermatoglyphics, Nephrotic syndrome, Steroids, Pediatrics
Abstract
Background: Although the association between the type of idiopathic nephrotic syndrome (INS) and a peculiar pattern of fingerprints digital would suggest the presence of genetic factors related to both, this has not been previously studied. This study aimed to evaluate if there are fingerprints patterns differences between children with steroid-resistant INS (SRNS) and those with steroid-sensitive INS (SSNS).
Methods: The frequencies distribution of arches, ulnar loops, radial loops, and whorls was studied in 60 children with SRNS, and 60 children with SSNS. Bivariate analysis to detect the relationship between each fingerprint pattern with the study groups was performed by chi-square test and to evaluate its possible association, the odds ratios (OR) were calculated with 95% confidence’s intervals (95%CI).
Results: The patients with SRNS had a higher frequency of digital whorls compared with that of patients with SSNS (46.7% vs. 30.7%, p = 0.005). Additional comparisons using a “whorls excesses” definition obtained from normative data in our population (≥ 7 whorls in females or ≥ 8 in males) were associated with increased odds for SRNS (OR 2.96, 95% CI 1.15-7.61).
Conclusions: Our findings indicate that there are differences between children with SRNS and SSNS at the level of digital dermatoglyphics, but further studies are needed to confirm this association and its possible implications.
References
Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney Int. 1978;13(2):159-65.
Elie V, Fakhoury M, Deschênes G, Jacqz-Aigrain E. Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives. Pediatr Nephrol. 2012; 27(8):1249-56.
Eddy AA, Symons JM. Nephrotic syndrome in childhood. Lancet. 2003; 362(9384):629-39.
Davin JC, Rutjes NW. Nephrotic syndrome in children: from bench to treatment. Int J Nephrol. 2011; 2011:372304.
Preus M, Fraser C. Dermatoglyphics and syndromes. Am J Dis Child. 1972; 124(6):933-43.
Saxena RS, David MP, Indira AP. Dermatoglyphic evaluation in subjects and parents of cleft lip with and without cleft palate. Cleft Palate Craniofac J. 2013; 50(6):e105-10.
Luna PC, Larralde M. Profuse congenital familial milia with absent dermatoglyphics (Basan’s Syndrome): description of a new family. Pediatr Dermatol. 2012; 29(4):527-9.
de Bruin EI, de Nijs PF, Verhulst FC, Huizink AC. The association between formal thought disorder and finger print asymmetry in children with a psychiatric disorder: an exploratory study. Eur Child Adolesc Psychiatry. 2012; 21(12):691-8.
Sariri E, Kashanian M, Vahdat M, Yari S. Comparison of the dermatoglyphic characteristics of women with and without breast cancer. Eur J Obstet Gynecol Reprod Biol. 2012; 160(2):201-4.
Garay-Cortés M. Dermatoglifos palmares y digitales en niños con síndrome nefrótico idiopático. Tesis de Especialidad en Pediatría Médica no publicada. Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México, 2009.
The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr. 1981; 98(4):561-4.
Schaumann B, Alter M. Dermatoglyphics in medical disorders. New York, USA: Springer-Verlag; 1976.
Penrose LS. Memorandum on dermatoglyphic nomenclature. Birth Defects Orig Art Ser. 1968; 4(3): 1-13.
Corona E, Noriega MA, Totsuka SE, Ornelas ML, Pérez G, Pablos A, Ramírez EJ, Barajas LO, Padilla LM, Quintana ML. Dermatoglifología médica: estudio de referencia para una población estudiantil del occidente de México. Revista Archivos Facultad de Medicina Universidad de Guadalajara (México) 1983; 2(1):34-45.
Gbadegesin R, Smoyer WE. Nephrotic Syndrome. En: Geary DF, Schaefer F, editores. Comprehensive Pediatric Nephrology. Philadelphia, USA: Mosby, 2008; p. 205-18.
Nussbaum RL, McInnes RR, Willard HF. Thompson & Thompson. Genética en medicina. 7ª. ed. Barcelona, España: Elsevier, España, 2008; p. 151-74.
Corona-Rivera JR, Coello-Ramírez P, Corona-Rivera A, Larrosa-Haro A, et al. Dermatoglifos palmares en niños con constipación crónica idiopática. Bol Med Hosp Infant Mex. 1996; 53(1):24-7.