Relationship between BCG vaccination and increased mortality from COVID-19. An ecological fallacy?
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Keywords
SARS Virus, Coronavirus Infections, Ecological Studies, Epidemiologic Studies, Epidemiologic Factors, COVID-19
Abstract
Ecological studies are one of the most common study designs used to establish the association between certain factors and disease development. However, they have limitations mainly on how to measure the variables, so their results must be verified in studies with greater validity. Therefore, the study that links the possible relationship between higher mortality from COVID-19 and non-vaccination by bacillus Calmette-Guérin (BCG) that was recently published, remains in doubt due to the lack of rigor in the methodology used.
References
Miller A, Reandelar MJ, Fasciglione K, Roumenova V, Li Y, Otazu GH. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19:an epidemiological study. MedRxiv. 2020. Disponible en:https://www.medrxiv.org/content/10.1101/2020.03.24.20042937v2. doi:https://doi.org/10.1101/2020.03.24.20042937
Moorlag SJCFM, Arts RJW, van Crevel R, Netea MG. Non-specific effects of BCG vaccine on viral infections. Clin Microbiol Infect. 2019;25:1473-8. doi:10.1016/j.cmi.2019.04.020
Washio M, Oura A, Mori M. Ecological studies on influenza infection and the effect of vaccination:their advantages and limitations. Vaccine. 2008;26(50):6470-2. doi:10.1016/j.vaccine.2008.06.037
Neumark Y. What can ecological studies tell us about death?Isr J Health Policy Res. 2017;6(1):52. doi:10.1186/s13584-017-0176-x
Salkeld DJ, Antolin MF. Ecological fallacy and aggregated data:a case study of fried chicken restaurants, obesity and Lyme disease. Ecohealth. 2020;17(1):4-12. doi:10.1007/s10393-020-01472-1
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