Zika, a neurotropic virus?
Main Article Content
Keywords
Arboviruses, Arbovirus infections, Epidemiological surveillance, Epidemiology
Abstract
In this paper, the neurotropism potential Zika virus is discussed, by comparison with viruses both RNA and DNA are neurotropic known, also it is said that compared with the new viruses that have affected the Americas, as the chikungunya, Zika has shown great affinity by brain tissue, manifested by a high incidence of acute neurological conditions, such as Guillain-Barré syndrome, among others, as well as the reported incidence of microcephaly that is abnormally high compared with the previous incidence, which, in a stillborn subject necropsied significant alterations demonstrated in brain tissue, identifying viral material and live virus in the fetoplacental complex, and demonstrating the impact both white matter and gray matter as well as basal ganglia, corpus callosum, ventricles and spinal cord, which could explain the microcephaly that concerns him. Although not a direct cause-effect relationship is demonstrated, however current evidence supports that relationship, hoping to be supported scientifically.
References
Castellanos J., Bello J., Velandia-Romero, M. Manifestaciones neurológicas durante la infección por el virus del dengue. Infectio. 2014; 18(4) 167-176.
González Duarte A. Viejos enemigos, nuevos retos: virus neurotrópicos en el siglo XXI. Rev Mex Neuroci 2010; 11(2): 136-140
Salamano, R. & Lewin, S. Las encefalitis herpéticas. Encefalitis producidas por la familia herpes. Arch Med Interna 2011; XXXIII (3):49-58
Oehler E, Fournier E, Leparc-Goffart I, et-al. Increase in cases of Guillain-Barré syndrome during a Chikungunya outbreak, French Polynesia, 2014 to 2015. Euro Surveill. 2015;20(48):pii=30079. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2015.20.48.30079
Romero-Santacruz E, Lira-Canul JJ, Pacheco-Tugores F, Palma-Chan AG. Dengue neonatal. Presentación de casos clínicos. Ginecol Obstet Mex 2015;83:308-315.
Restrepo-Jaramillo BN. Infección por el virus del Chikungunya. Rev CES Med. 2014; 28(2):313-323
Mlakar J, Korva M, Tul N, et-al. Zika virus associated with microcephaly. NEJM. February 10, 2016 DOI: 10.1056/NEJMoa1600651
Fauci, AS & Morens, DM. Zika Virus in the Americas - Yet Another Arbovirus Threat. NEJM. January 13, 2016DOI: 10.1056/NEJMp1600297
Rodriguez-Morales AJ, Zika and microcephaly in Latin America: An emerging threat for pregnant travelers? Travel Medicine and Infectious Disease (2016). http://dx.doi.org/10.1016/j.tmaid.2016.01.011
Petersen, LR, Jamieson, DJ, Powers, AM, et-al. Zika Virus. NEJM, 30 marzo 2016. 10.1056/NEJMra1602113.