Six-minute walk test in children with neuromuscular disease
Main Article Content
Keywords
Neuromuscular disease, Respiratory function tests, Child
Abstract
Background: neuromuscular diseases affect the motor unit. When they evolve, respiratory complications are common; the six-minute walk test plays an important role in the assessment of functional capacity.
Methods: prospective, transversal, descriptive and observational study. We studied seven children with a variety of neuromuscular diseases and spontaneous ambulation. We tested their lung function, and administered a six-minute walk test and a test of respiratory muscle strength to these children.
Results: the age was 9.8 ± 2.4 years. All patients were males. Forced vital capacity decreased in three patients (42.8 %), forced expiratory volume during the first second (2.04 ± 1.4 L) and peak expiratory flow (4.33 ± 3.3 L/s) were normal. The maximum strength of respiratory muscles was less than 60 % of predicted values. The distance covered in the six-minute walk test was lower when compared with healthy controls (29.9 %).
Conclusions: the six-minute walk test can be a useful tool in early stages of this disease, since it is easy to perform and well tolerated by the patients.
References
Kleinsteuber K, Avaria MA. Enfermedades neuromusculares en pediatría. Rev Pediatr Elec. 2005;2 (1):52-61.
Cammarata-Scalis F, Camacho N, Alvarado J, Lacruz-Rengel M. Distrofia muscular de Duchenne, Presentación clínica. Rev Chil Pediatr. 2008;79(5): 495-501.
Domínguez M, Luna E, Peñalosa L, Galicia S, Toral S, Baños B, et al. Guía para el diagnóstico y tratamiento de las alteraciones respiratorias en las enfermedades neuromusculares. Neumol Cir Torax. 2011;70(1):5-66.
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS Statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111-17.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38.
Black LF, Hyatt RE. Maximal respiratory pressures. Normal values and relationship to age and sex. Am Rev Respir Dis. 1969;99(5):696-702.
Szeinberg A, Marcotte JE, Roizin H, Mindorff C, England S, Tabachnik E, et al. Normal values of maximal inspiratory and expiratory pressures with a portable apparatus in children, adolescents, and young adults. Pediatr Pulmonol. 1987;3(4):255-8.
Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4-11 year of age. Arch Dis Child. 2008;93(6): 464-8.
McDonald C, Henricson EK, Han JJ, Abresch RT, Nicorici A, Atkinson L, et al. The 6-minute walk test in Duchenne/Becker muscular dystrophy: longitudinal observations. Muscle Nerve. 2010;42(6):966-74.
McDonald CM, Henricson EK, Han JJ, Abresch RT, Nicorici A, Elfring G, et al. The 6-minute walk test as a new outcome measure in Duchenne muscular dystrophy. Muscle Nerve. 2010;41(4):500-10.
Geiger R, Strasak A, Treml B, Gasser K, Kleinsasser A, Fischer V, et al. Six-minute walk test in children and adolescents. J Pediatr. 2007;150(5):395-9.
Li AM, Yin J, Au JT, So HK, Tsang T, Wong E, et al. Standard reference for the six-minute-walk test in healthy children aged 7 to 16 years. Am J Respir Crit Care Med. 2007;176(2):174-80. Texto libre en http://www.atsjournals.org/doi/abs/10.1164/rccm.200607-883OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Escobar M, López A, Véliz C, Cristomo S, Pinochet R. Test de marcha en 6 minutos en niños chilenos sanos. Kinesiologia 2001;62:16-20.
Iwama AM, Andrade GN, Shima P, Tanni SE, Godoy I, Dourado VZ. The six-minute walk test and body weight-walk distance product in healthy Brazilian subjects. Braz J Med Biol Res. 2009;42(11):1080-5. Texto libre en http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009005000032&lng=en&nrm=iso&tlng=en
Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2000;161(2 Pt 1):487-92. Texto libre en http://www.atsjournals.org/doi/abs/10.1164/ajrccm.161.2.9906015?url_ver=Z39.88-2003&rfr_id =ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&
Lederer DJ, Arcasoy SM, Wilt JS, D’Ovidio F, Sonett J, Kawut SM. Six-minute-walk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174(6):659-64. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648057/
Rejbi IB, Trabelsi Y, Chouchene A, Ben Turkia W, Ben Saad H, Zbidi A, et al. Changes in six-minute walking distance during pulmonary patients with COPD and in healthy subjects. Int J Chron Obstruct Pulmon Dis. 2010;9(5):209-15. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921688/
Salhi B, Troosters T, Behaegel M, Joos G, Derom E. Effects of pulmonary rehabilitation in patients with restrictive lung disease. Chest. 2010;137(2):273-9.
Vargas-Domínguez C, Gochicoa-Rangel L, Velázquez-Uncal M, Mejía-Alfaro R, Vázquez-García JC, Pérez-Padilla R, et al. Pruebas de función respiratoria, ¿cuál y a quién? Neumol Cir Torax. 2011;70(2): 101-17.
Gutiérrez M, Beroíza T, Cartagena C, Cavides I, Céspedes J, Gutiérrez M, et al. Prueba de caminata de seis minutos. Rev Chil Enferm Respir. 2009;25(1):15-24.
Dourado VZ, Antunes LC, Tanni SE, de Palva SA, Padovani CR, Godoy I. Relationship of upper-limb and thoracic muscle strength to 6-min walk distance in COPD patients. Chest. 2006;129(3):551-7. Texto libre en http://journal.publications.chestnet.org/article.aspx?articleid=1084365
Cruz-Anleu ID, Baños-Mejía BO, Galicia-Amor S. Descripción de las características de la capacidad funcional en niños con distrofia muscular de Duchenne. Bol Pediatr. 2012;52(291):23-8. Texto libre en http://www.sccalp.org/documents/0000/1837/Bol Pediatr2012_52_23_28.pdf