Moebius syndrome. Clinical case report
Main Article Content
Keywords
Mobius syndrome, Facial paralysis
Abstract
Background: Moebius syndrome (MBS) is an infrequent disease, having an incidence of 1 in 10 000 births, mainly characterized by a congenital bilateral facial paralysis due to an agenesia of the sixth and seventh cranial nerves. In addition, orofacial and limb anomalies are frequently found in these patients. The diagnosis is fundamentally based on different clinical manifestations of the disorder.
Clinical case: a female newborn with the clinical picture of Moebius syndrome is presented, and genetic or environmental aspects are discussed. Since the use of misoprostol for abortion and inducing uterine activity in combination with NSAIDs, the number of newborns with MBS associated with this drug has increased. Nowadays, either genetic or environmental factors are associated with MBS.
Conclusions: it is necessary that the general and medical community
be aware of the risk of teratogenic effects of misoprostol, and the usefulness of genetic counseling whenever there is a newborn with Moebius syndrome.
References
Milet LB, Alegría PX. Síndrome de Moebius. Rev. Obstet. Ginecol. 2006;1(3):215-6. Texto libre: http://www.revistaobgin.cl/articulos/ver/406
Villafranca AJ, Castillo DP, Garcés SM, Villalón FE, Grez LE, Díaz GA. Síndrome de Moebius. Rev. Chilena de Cirugía. 2003;55(1):75-80. Texto libre: http://www.cirujanosdechile.cl/Revista/PDF%20Cirujanos %202003_01/Cir.1_2003%20S%EDndrome%20de% 20Moebius.pdf
Gómez-Valencia L, Morales-Hernández A, Cornelio-García RM, Toledo-Ocampo E, Briceño-González MR, Rivera-Ángeles MM. Estudio clínico y genético del síndrome de Moebius. Bol Med Hosp Infant Mex. 2008;65:353-7. Texto libre: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665 -11462008000500004
Singham J, Manktelow R, Zuker RM. Möbius Syndrome. Seminars in Plastic Surgery. 2004;18(1):39-46. Texto libre: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884693/
Camacho-Ramírez RI, Ávila-Reyes R, González-Cavazos L, Plascencia-Valadéz V, Trejo-Belmonte R, Yunes-Zárraga JLM, et al. Síndrome de Moebius. Archivos de Investigación Pediátrica de México 2007;10(1): 16-20. Texto libre: http://www.imbiomed.com/1/1/articulos.php?id_revista=119&id_ejemplar=4787
Pottie K. Is misoprostol teratogenic? Misoprostol use during early pregnancy and its association with Möbius’ syndrome. Canadian Family Physician. 1999;45: 315-6. Texto libre: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2328264/
Verzijl HT, Padberg GW, Zwarts MJ. The spectrum of Möbius syndrome: an electrophysiological study. Brain. 2005;128:1728-36.
Van der Zwaag B, Verzijl HT, Beltran-Valero BD, Schuster VL, H Van Bokhoven H, Kremer H, et al. Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10. J Med Genet. 2002; 39:30. Texto libre: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735152/
Verzijl HT, Van den Helm B, Veldman B, Hamel BCJ, Kuyt LP, Padberg GW, et al. A Second Gene for Autosomal Dominant Möbius Syndrome is Localized to Chromosome 10q in a Dutch Family. Am J. Hum Genet. 1999;65:752-6. Texto libre: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377982/
Carrillo-Hernández CA, Romo Chávez HF. Síndrome de Moebius. Revista de especialidades médico-quirúrgicas. 2010;15(4):261-5.