Perinatal infection by rubella virus in breast-fed babies with congenital heart disease
Main Article Content
Keywords
Rubella syndrome, congenital, Heart defects congenital, Infant
Abstract
Background: seroepidemiological surveys suggest that approximately 20 % of women of childbearing age are susceptible to rubella. It is necessary to detect congenital rubella cases. Our objective was to determine the frequency of perinatal infection by rubella virus (RV) in infants with congenital heart disease.
Methods: prospective, cross-sectional study. We studied hospitalized and outpatients from September 2007 to December 2008. Neonates and infants under one year of age with congenital heart disease were included. A blood sample of 3 mL was taken from mother-child binomial and micro-ELISA for IgG and IgM against rubella were performed
Results: 80 patients were studied, 56 % were female, with a median age of 3 months. More frequent congenital heart disease was ventricular septal defect (28.5 %), followed by atrial septal defect (17.5 %). Median maternal age was 28 years old. A history of febrile illness and rash during pregnancy was positive in 1.25 %. 7 cases of perinatal infection by RV were detected, three met the criteria for congenital rubella syndrome, and four had only congenital heart disease.
Conclusions: the search for cases of congenital rubella syndrome in newborns and infants with heart disease could be used as a strategy to detect non-obvious cases.
References
Banatvala JE, Brown DW. Rubella. Lancet. 2004;363(9415):1127-37.
Webster WS. Teratogen update: congenital rubella. Teratology. 1998;58(1):13-23.
Katow S. Rubella virus genome diagnosis during pregnancy and mechanism of congenital rubella. Intervirology. 1998;41(4-5):163-9.
Bullens D, Smets K, Vanhaesebruck P. Congenital rubella syndrome after maternal reinfection. Clin Pediatr. 2000;39(2):113-6.
Zimmerman L, Reef SE. Incidence of congenital rubella syndrome at a hospital serving a predominantly Hispanic population, El Paso Texas. Pediatrics. 2001;107(3):E40-4.
Blitchen D, González P, Rodríguez R, Matos J, Santillán M. Síndrome de rubéola congénita en 17 hospitales del Perú, 1998-2000. Anales de la Facultad de Medicina Universidad de San Marcos. 2002;63(3):1-8. Texto libre en http://www.bvsde.paho.org/texcom/cd051477/blitchsi.pdf
Banerji A, Ford-Jones EL, Kelly E, Robinson JL. Congenital rubella syndrome despite maternal antibodies. CMAJ. 2005;172(13):1678-9. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150255/
Solórzano-Santos F, López-Kirwan A, Álvarez-y Muñoz MT, Miranda-Novales MG, Gadea-Álvarez T, Vázquez-Rosales G. Síndrome de rubéola congénita en lactantes atendidos en un hospital pediátrico. Gac Med Mex. 2001;137(2):105-9.
Gutiérrez-Trujillo G, Muñoz O, Tapia-Conyer R, Bustamante-Calvillo ME, Álvarez-y Muñoz MT, Guiscafré-Gallardo JP, et al. The seroepidemiology of rubella in Mexican women. A national probability survey. Salud Publica Mex. 1990;32(6):623-31.
Macías-Hernández AE, Ponce de León S, Muñoz-Barrett JM, López-Jiménez F, Cano-Castro A, Vera-Peña A, et al. Seroepidemiología de la rubéola en una población femenina en edad reproductiva en León, Guanajuato. Salud Publica Mex. 1993;35(4):339-44.
Sagarnaga-Durante D, Delgado-Monge C, Sáenz-Flores G, Tufiño-Olivares E, Levario-Carrillo M. Frecuencia de anticuerpos contra el virus de la rubéola en mujeres en puerperio. Ginecol Obstet Mex. 2004;72(9):445-9.
Nessa A, Islam MN, Tabassum S, Munshi SU, Ahmed M, Karim R. Seroprevalence of rubella among urban and rural Bangladeshi women emphasises the need for rubella vaccination of pre-pubertal girls. Indian J Med Microbiol. 2008;26(1):94-5.
Caidi H, Bloom S, Azilmaat M, Benjouad A, Reef S, El Aouad R. Rubella seroprevalence among women