Autoimmune blistering dermatosis as a paraneoplastic syndrome secondary to testicular cancer
DOI:
https://doi.org/10.5281/zenodo.11397264Keywords:
Skin Diseases, Blister, NeoplasmsAbstract
Background: In this case report, the connection between autoimmune bullous dermatosis acting as a paraneoplastic syndrome and testicular cancer is highlighted.
Clinical case: A 28-year-old man with no chronic-degenerative diseases or medication consumption presented with erythematous macules and blisters on the chest, spreading to the back and limbs. Physical examination revealed eyelid erythema, conjunctival injection, ulcers on the tongue and lips, and blisters that denuded 90% of the body surface. He was admitted to the intensive care unit, where he was diagnosed and treated as toxic epidermal necrolysis. He received immunosuppressive treatment, with symptomatic improvement and re-epithelialization of the skin lesions. In the internal medicine service, a malignant testicular tumor was identified, for which he underwent orchiectomy, with the histopathological result of seminoma.
Conclusions: It is concluded that the dermatological manifestations were probably secondary to an autoimmune bullous dermatosis, given that the patient had no infectious processes or recent drug use, in addition to the recent diagnosis of germ cell tumor. Highlights of this clinical case include the simultaneous identification of bullous disease and neoplasia during the same hospitalization, supporting the correlation between both entities, as has been observed in previous cases.
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