Studying the answer to SARS-CoV-2 in in vitro and in vivo models helps understanding why this virus causes more morbidity and mortality than others
DOI:
https://doi.org/10.24875/RMIMSS.M20000123Keywords:
SARS Virus, BCG Vaccine, In Vitro Techniques, Morbidity, /mortalityAbstract
In vitro and in vivo studies show that SARS-CoV-2 induces a suppressed antiviral immune response, which may be one of the reasons the infection causes more severe damage in immunocompromised and elderly patients. Also, it is suggested that the BCG vaccine could be an alternative to stimulate the suppressed antiviral response in patients infected with SARS-CoV-2.
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Blanco-Melo D, Nilsson-Payant BE, Liu WC, Møller R, Panis M, Sachs D, et al. SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems. bioRxiv preprint doi: https://doi.org/10.1101/2020.03.24.004655
Miller A, Reandelar MJ, Fasciglione K, Roumenova V, Li Y, and Otazu GH. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study. medRxiv preprint doi: https://doi.org/10.1101/2020.03.24.20042937
Mathurin KS, Martens GW, Kornfeld H and Welsh RM. CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses. J. Virol 2009;83: 3528-39.
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