XIII. Research Design in the Structured Review of an Article
Main Article Content
Keywords
Research design, Clinical trial, Causality, Bias
Abstract
The quality of information obtained according to the research design is integrated to the structured review in accordance with the causality model. For example, it is used in the article “Reduction in the incidence of post-stroke nosocomial pneumonia by using the ‘Turn-mob’ Program”, whose design corresponds to a clinical trial. The aspects that have to be identified and analyzed include ethical issues, which are intended to safeguard the safety and respect for the patient; the random assignment, intended to generate groups with homogeneous baseline conditions, comprised by subjects with the same probability of receiving any of the maneuvers being compared and with the same pre-maneuver likelihood of adherence to them and the same chances of dropping out from the study for causes other than the maneuver. Other aspects include the relativity of the comparison, the blinding of the maneuver, the application in parallel of the comparative maneuver, the early termination and the analysis according to the degree of adherence. The analysis according to research design is supplementary to that performed on the basis of the causality architectural model and statistical and clinical relevance considerations
References
Talavera JO. Clinical research I. The importance of the research design. Rev Med Inst Mex Seguro Soc. 2011;49(1):53-8.
Talavera JO, Wacher-Rodarte NH, Rivas-Ruiz R. Clinical research III. The causality studies. Rev Med Inst Mex Seguro Soc. 2011;49(3):289-94.
Feinstein AR. Clinical epidemiology. The architecture of clinical research. Philadelphia: WB Saunders; 1985.
Feinstein AR. Clinical biostatistics. Washington: C.V.Mosby; 1977.
Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. Third ed. Baltimore: Williams & Wilkins; 2008.
Portney LG, Watkins MP. Foundations of clinical research: applications to practice. Third edition. Pearson/Prentice Hall; 2009.
Talavera JO, Rivas-Ruiz R. Clinical research VIII.Structured review of an article. Rev Med Inst Mex Seguro Soc. 2012;50(2):163-6.
Talavera JO, Rivas-Ruiz R. Clinical research IX.From the clinical judgment to the clinical trial. Rev Med Inst Mex Seguro Soc. 2012;50(3):267-72.