B lymkphocyte simulator in systemic lupus erythematosus

Main Article Content

Ulises Mercado
<p>Hospital General Mexicali, Instituto de Servicios de Salud P&uacute;blica del Estado de Baja California, Secretar&iacute;a de Salud, Mexicali, Baja California</p>

Keywords

Lupus erythematosus, systemic, Autoimmunity, B lymphocyte

Abstract

The B lymphocyte stimulator (BLyS) is an essential protein for the growth and survival of B cells. BLyS is expressed on monocytes, macrophages, and dendritic cells. BLyS binds to three receptors on B cells: BAFF-R, BCMA, and TACI. BLyS overexpression in mice leads to lupus-like syndrome, but not in all, whereas BLyS deficient mice results in a block of B cell development. High serum levels of BLyS can be detected in patients with lupus and rheumatoid arthritis. BLyS antagonists are an attractive target for treating autoimmune diseases.

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References

Hahne M, Katahoka T, Schroter M, Hofmann K, Irmler M, Bodmer I, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med 1998;188(6):1185-1190. Disponible en http://www.ncbi. nlm.nih.gov/pmc/articles/PMC2212534/

 

Dörner T, Putterman C. B cells, BAFF/zTNF, TACI, and systemic lupus erythematosus. Arthritis Res 2001;3(4): 197-199. 

 

Khare SD, Sarosi I, Xia XZ, McCabe S, Miner K, Solovyev I, et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci USA 2000;97(7):3370-3375. Disponible en http://www.ncbi.nlm. nih.gov/pmc/articles/PMC16246/?tool=pmcentrez

 

Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Stohl W, et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999;190(11):1697-1710. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195729/? tool=pmcentrez

 

Verfolomeev E, Kischkel F, Martin F, Seshasayee D, Wang H, Lawrence D, et al. APRIL-deficient mice have normal immune system development. Mol Cell Biol 2004 (3);24:997-1006. Disponible en http://www.ncbi.nlm.nih. gov/pmc/articles/PMC321448/?tool=pmcentrez

 

Groom JR, Fletcher CA, Walters SN, Grey ST, Watt SV, Sweet MJ, et al. BAFF and MyD88 signals promote a lupus like disease independent of T cells. J Exp Med 2007; 204(8):1959-1971. Disponible en http://www.ncbi.nlm.nih. gov/pmc/articles/PMC2118661/?tool=pmcentrez

 

Stohl W. Systemic lupus erythematosus and its ABCs (APRIL/BLyS complexes). Arthritis Res Ther 2010;12(2):111. Disponible en http:/www.ncbi.nlm.nih.gov/pmc/articles/PMC2888214/

 

Marston B, Looney RJ. Connective tissue diseases. Translating the effects of BAFF in SLE. Nature Rev Rheumatol 2010;6(9):503-504

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PDF (Spanish)
Issue
Vol. 50 No. 4 (2012): July-August
Section
Editorial

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How to Cite

1.
Mercado U. B lymkphocyte simulator in systemic lupus erythematosus. Rev Med Inst Mex Seguro Soc [Internet]. 2017 Jan. 24 [cited 2025 Jul. 15];50(4):349-50. Available from: https://revistamedica.imss.gob.mx/index.php/revista_medica/article/view/1167