Hematopietic cells raising with plerixafor in non-Hodgkin lymphoma

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Uendy Pérez-Lozano
<p>Servicio de Hematolog&iacute;a, Hospital de Especialidades, Instituto Mexicano del Seguro Social,&nbsp;Puebla, Puebla</p>

Francisco Tripp-Villanueva
<p>Servicio de Hematolog&iacute;a, Hospital de Especialidades, Centro M&eacute;dico Nacional La Raza,&nbsp;Instituto Mexicano del Seguro Social,&nbsp;Ciudad de M&eacute;xico</p>

Aline Ramírez-Alvarado
<p>Servicio de Hematolog&iacute;a, Hospital de Especialidades, Centro M&eacute;dico Nacional La Raza,&nbsp;Instituto Mexicano del Seguro Social,&nbsp;Ciudad de M&eacute;xico</p>

Jorge Vela-Ojeda
<p>Servicio de Hematolog&iacute;a, Hospital de Especialidades, Centro M&eacute;dico Nacional La Raza,&nbsp;Instituto Mexicano del Seguro Social,&nbsp;Ciudad de M&eacute;xico</p>

Alejandro Limón-Flores
<p>Servicio de Hematolog&iacute;a, Hospital de Especialidades, Instituto Mexicano del Seguro Social,&nbsp;Puebla, Puebla</p>

José Luis Kramis-Cerezo
<p>Direcci&oacute;n M&eacute;dica, Genzyme M&eacute;xico, Ciudad de M&eacute;xico</p>

Keywords

Lymphoma, non-Hodgkin, Transplantation, autologous, Hematopoietic stem cells

Abstract

Background: bone marrow autologous transplantation (BMAT) has proven benefits in patients treated for non-Hodgkin’s lymphoma (NHL). Plerixafor is an inhibitor of CXCR4 receptor. The aim was to report the raise of hematopoietic cells with plerixafor in patients with NHL.

Clinical cases: patient 1 with follicular NHL, GI, intermediate FLIPI, CD20+, CD45+, BCL-2+, who reached complete response after three chemotherapy regimes. Mobilization failed after use of filgrastim (G-CSF) alone and G-CSF + cyclophosphamide. A new attempt was made with G-CSF + plerixafor (G-CSF, 10 µg/kg for 7 days + plerixafor, 240 µg/kg in days 4 to 7). Patient 2 with follicular NHL and CD20+ reached complete remission with MINE after therapeutic failure with other regimes, but develops severe marrow toxicity. Mobilization was supported with G-CSF 10 µg/kg/d + plerixafor in days 4 and 5. In case one, proper cell counts where obtained after three aphaeresis. In the second case, two harvests add of 2.7 × 106/kg were obtained.

Conclusions: plerixafor raised the hematopoietic stem cells in peripheral blood and improves mobilization of proper cell population.

Abstract 178 | PDF (Spanish) Downloads 82

References

Steinberg M, Silva M. Plerixafor: a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-Hodgkin’s lymphoma or multiple myeloma. Clin Ther 2010; 32(5):821-843.

 

Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, et al. Rapid mobilization of functional donor hemato-poietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood 2008;112(4):990-998. Disponible en http://bloodjournal.hematologylibrary. org/content/112/4/990.long

 

Worel N, Rosskopf K, Neumeister P, Kasparu H, Nachbaur D, Russ G, et al. Plerixafor and granulocyte-colony-stimula-ting factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a named patient program. Transfusion 

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Issue
Vol. 50 No. 4 (2012): July-August
Section
Reporte breve

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How to Cite

1.
Pérez-Lozano U, Tripp-Villanueva F, Ramírez-Alvarado A, Vela-Ojeda J, Limón-Flores A, Kramis-Cerezo JL. Hematopietic cells raising with plerixafor in non-Hodgkin lymphoma. Rev Med Inst Mex Seguro Soc [Internet]. 2017 Jan. 24 [cited 2025 Jul. 15];50(4):449-51. Available from: https://revistamedica.imss.gob.mx/index.php/revista_medica/article/view/1186