The treatment of hypercholesterolemia is in a crossroad

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Laura C. Bonifaz

Keywords

Nobel Prize, Dendritic cells, Immunotherapy

Abstract

Ralph M. Steinman was the recipient of the 2011 Nobel Prize of Physiology and Medicine due to the discovery of dendritic cells, which have a crucial role on the onset of acquired immunity, a fundamental event in the organism’s defense. Today, dendritic cells are used in the development of vaccines and in cancer therapy. Steinman’s contributions have been fundamental in the understanding of immunity.

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References

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Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002;196(12):1627-1638. Disponible en http://www.ncbi. nlm.nih.gov/pmc/articles/PMC2196060/?tool=pubmed

 

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