Choroidal calcification associated to chondrocalcinosis

Main Article Content

Julia Neftalí Pérez-Zavala
Julio Alejandro Blanco-D’Mendieta
Manuela Alejandra Flores-Peraza
Elizabeth Calderón-Taboada

Keywords

Calcification, Physiologic, Chondrocalcinosis, Hyperparathyroidism, Eye Diseases

Abstract

Introduction: Chondrocalcinosis is a common joint condition in people over 50, characterized by the deposition of calcium pyrophosphate crystals that causes calcification in cartilage structures. Although its prevalence in the general population is 5%, sclerochoroidal calcifications are a rare finding in this pathology.

Objective: Describe the case of a 60-year-old man with choroidal calcification in the left eye, associated with radiological findings of chondrocalcinosis, whose metabolic report showed parameters compatible with hyperparathyroidism.

Clinical case: Male patient from Mexico City, smoker for 45 years, with medical history of calcium pyrophosphate deposition disease at age 16, attended routine eye examination. A left eye funduscopy revealed an irregularly shaped white-yellowish subretinal lesion with well-defined edges inside the upper temporal arch. Ophthalmological paraclinical studies were performed, and a choroidal hyperreflectic paramacular plate image, which did not involve the retina layers, was corroborated with five-line optical coherence tomography.

Conclusions: Although the lesions are asymptomatic and do not require treatment, it is of great importance to make a differential diagnosis with choroidal metastases, choroidal melanoma, choroidal osteoma and lymphoma, since these pathologies do require more aggressive treatment.

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References

Rotés-Querol, J, Muñoz-Gómez J. Tratamiento de las enfermedades reumáticas. 1a Ed. Barcelona: Toray; 1971.

 

Resnick D. Diagnosis of bone and joint disorders. Philadelphia, Pa.: W.B. Saunders; 1995.

 

Czarnitzki TG. Condrocalcinosis. Revista Argentina de Artroscopia. 2002;9(2):72-79.

 

Parperis K, Carrera G, Baynes K, Mautz A, Dubois M, Cerniglia R et al. The prevalence of chondrocalcinosis (CC) of the acromioclavicular (AC) joint on chest radiographs and correlation with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Clinical Rheumatology. 2013;32(9):1383-1386. DOI: 10.1007/s10067-013-2255-x

 

Neame RL. UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte. Annals of the Rheumatic Diseases. 2003;62(6):513-518. DOI: 10.1136/ard.62.6.513

 

Canoso JJ. Enfermedad por depósito de pirofosfato cálcico: 60 pacientes mexicanos. An Med Mex. 2016;61(3):188-194.

 

Thouverey C, Bechkoff G, Pikula S, Buchet R. Inorganic pyrophosphate as a regulator of hydroxyapatite or calcium pyrophosphate dihydrate mineral deposition by matrix vesicles. Osteoarthritis and Cartilage. 2009;17(1):64-72. DOI: 10.1016/j.joca.2008.05.020

 

Fernandez-Dapica MP, Gomez-Reino JJ. Familial chondrocalcinosis in the Spanish population. J Rheumatol. 1986;13(3):631-633.

 

Zhang Y, Brown MA. Genetic studies of chondrocalcinosis. Current Opinion in Rheumatology. 2005;17(3):330-335. DOI: 10.1097/01.bor.0000157042.19740.f4

 

Jones AC, Chuck AJ, Arie EA, Green DJ, Doherty M. Diseases associated with calcium pyrophosphate deposition disease. Seminars in Arthritis and Rheumatism. 1992;22(3):188-202. DOI: 10.1016/0049-0172(92)90019-a

 

Timms AE. Genetic studies of disorders of calcium crystal deposition. Rheumatology. 2002;41(7):725-729. DOI: 10.1093/rheumatology/41.7.725

 

Ryan LM, Rosenthal AK. Metabolism of extracellular pyrophosphate. Current Opinion in Rheumatology. 2003;15(3):311-314. DOI: 10.1097/00002281- 200305000-00020

 

Shields JA, Shields CL. CME Review: Sclerochoroidal Calcification. Retina. 2002;22(3):251-261. DOI: 10.1097/00006982-200206000-00001

 

Lee H, Kumar P, Deane J. Sclerochoroidal calcification associated with Albrights hereditary osteodystrophy. BMJ Case Reports. 2012;2012:bcr0320126022. DOI: 10.1136/bcr-03-2012-6022

 

Shields CL, Hasanreisoglu M, Saktanasate J, Shields PW, Seibel I, Shields JA. Sclerochoroidal Calcification. Retina. 2015;35(3):547-554. DOI: 10.1097/iae.0000000000000450

 

Honavar SG, Shields CL, Demirci H, Shields JA. Sclerochoroidal Calcification. Archives of Ophthalmology. 2001;119(6):833-840. DOI: 10.1001/archopht.119.6.833

 

Wong CM, Kawasaki BS. Idiopathic Sclerochoroidal Calcification. Optometry and Vision Science. 2014;91(2):e32-e37. DOI: 10.1097/OPX.0000000000000125

 

Lim JI, Goldberg MF. Idiopathic sclerochoroidal calcification. Case report. Arch Ophthalmol. 1989; 107(8):1122-3. DOI: 10.1001/archopht.1989.01070020188015

 

Carmeliet G, Cromphaut SV, Daci E, Maes C, Bouillon R. Disorders of calcium homeostasis. Best Pract Res Clin Endocrinol Metab. 2003;17(4):529-546. DOI: 10.1016/j.beem.2003.08.001

 

Eigelberger MS, Clark OH. Surgical Approaches To Primary Hyperparathyroidism. Endocrinology and Metabolism Clinics of North America. 2002;29(3):479-502. DOI: 10.1016/s0889-8529(05)70147-x

 

Shields JA. Sclerochoroidal Calcification in Calcium Pyrophosphate Dihydrate Deposition Disease (Pseudogout). Archives of Ophthalmology. 1997:115(8):1077- 1079. DOI: 10.1001/archopht.1997.01100160247021

 

Monnens L. Gitelman syndrome comes of age. Nephrology Dialysis Transplantation. 1998;13(7):1617-1619. DOI: 10.1093/ndt/13.7.1617

 

Calò L, Punzi L, Semplicini A. Hypomagnesemia and Chondrocalcinosis in Bartter’s and Gitelman’s Syndrome: Review of the Pathogenetic Mechanisms. American Journal of Nephrology. 2000;20(5):347-350. DOI: 10.1159/000013614

 

Gupta R. Sclerochoroidal calcification associated with Gitelman syndrome and calcium pyrophosphate dihydrate deposition. Journal of Clinical Pathology. 2005;58(12):1334-1335. DOI: 10.1136/jcp.2005.027300

 

Sierra-Rodríguez M, Fidalgo CB, Sáenz-Francés F, Romero JG, Bellido LM. Calcificaciones esclerocoroideas asociadas a hipovitaminosis D. Archivos de la Sociedad Española de Oftalmología. 2014;89(7):290-292. DOI: 10.1016/j.oftal.2012.12.016