Esophageal candidiasis in patients from a specialty hospital

Authors

  • Luis Javier Méndez-Tovar <p>Instituto Mexicano del Seguro Social, Hospital de Especialidades &ldquo;Dr. Bernardo Sep&uacute;lveda&rdquo;, Laboratorio de Investigaci&oacute;n M&eacute;dica en Dermatolog&iacute;a y Micolog&iacute;a. Ciudad de M&eacute;xico, M&eacute;xico</p>
  • José Froylán Rodríguez-Sánchez <p>Secretar&iacute;a de Salud, Instituto Nacional de Ciencias M&eacute;dicas y Nutrici&oacute;n Salvador Zubir&aacute;n, Departamento de Endoscop&iacute;a Gastrointestinal. Ciudad de M&eacute;xico, M&eacute;xico</p>
  • Patricia Manzano-Gayosso <p>Universidad Nacional Aut&oacute;noma de M&eacute;xico, Facultad de Medicina, Departamento de Microbiolog&iacute;a y Parasitolog&iacute;a. Ciudad de M&eacute;xico, M&eacute;xico</p>
  • Francisca Hernández-Hernández <p>Universidad Nacional Aut&oacute;noma de M&eacute;xico, Facultad de Medicina, Departamento de Microbiolog&iacute;a y Parasitolog&iacute;a. Ciudad de M&eacute;xico, M&eacute;xico</p>
  • Juan Manuel Blancas-Valencia <p>Instituto Mexicano del Seguro Social, Hospital de Especialidades &ldquo;Dr. Bernardo Sep&uacute;lveda&rdquo;, Departamento de Endoscop&iacute;a Gastrointestinal. Ciudad de M&eacute;xico, M&eacute;xico</p>
  • Israel Silva-González <p>Instituto Mexicano del Seguro Social, Hospital de Especialidades &ldquo;Dr. Bernardo Sep&uacute;lveda&rdquo;, Laboratorio Central. Ciudad de M&eacute;xico, M&eacute;xico</p>

Keywords:

Candidiasis, Esophagus, Candida albicans, Antifungal Agents

Abstract

Background: Esophageal candidiasis (EC) is the most common cause of infectious esophagitis. Its main risk factor has been HIV infection. In Mexico EC has been poorly studied.

Objectives: To determine the clinical and epidemiological characteristics of EC, and to identify its etiological agents as well as its antifungal susceptibility.

Methods: Patients who revealed the presence of scattered white spots through an upper gastrointestinal system endoscopy, in a period of one, in a tertiary care hospital, were included. Samples from patches were collected for microscopic examination, culture and susceptibility tests.

Results: Out of 1763 patients studied, 23 had scattered white spots; 13 were men; half of the patients were between the ages 20 to 40; main comorbidity was liver cirrhosis; use of omeprazole was significant. We obtained 22 isolates were obtained from 17 patients; the most frequent species were C. albicans (14) and C. parapsilosis (3). In five cases we found a two-species association v. g. Candida famata with Trichosporon mucoides). Half of the isolates showed resistance to antifungal drugs.

Conclusions: EC frequency in this study was similar to other studies’ results. Obtained isolates showed high resistance to azolic compounds and to caspofungin, which is relevant information to take a therapeutic decision.

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Published

2019-10-16

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Vol. 57 No. 2 (2019): March-April

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