Diagnosis and clinical implications of vascular calcification of chronic kidney disease in Mexico

Authors

  • Karla Vanesa Bañuelos-Chávez <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Renales.&nbsp;Guadalajara, Jalisco</p>
  • José Ignacio Cerrillos-Gutiérrez <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Departamento de Nefrolog&iacute;a y Trasplantes.&nbsp;Guadalajara, Jalisco</p>
  • Juan Carlos Nario <p>​Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Departamento de Radiolog&iacute;a e Imagen.&nbsp;Guadalajara, Jalisco</p>
  • Juan Abundis-Jiménez <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Departamento de Nefrolog&iacute;a y Trasplantes.&nbsp;Guadalajara, Jalisco</p>
  • Priscila Preciado-Rojas <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Departamento de Nefrolog&iacute;a y Trasplantes.&nbsp;Guadalajara, Jalisco</p>
  • Alejandro Campos-Mariz <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Renales.&nbsp;Guadalajara, Jalisco</p>
  • Laura Cortés-Sanabria <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Renales.&nbsp;Guadalajara, Jalisco</p>
  • Alfonso Martín Cueto-Manzano <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Renales.&nbsp;Guadalajara, Jalisco</p>
  • Enrique Rojas-Campos <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional de Occidente,&nbsp;Hospital de Especialidades,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Renales.&nbsp;Guadalajara, Jalisco</p>

Keywords:

Kidney Diseases, Diagnostic Techniques and Procedures, Vascular Calcification

Abstract

Vascular calcification (VC), it is a clinical condition highly associated to Chronic KidneyDisease (CKD), CKD patients had as a primary death cause, the cardiovascular disease(CVD), among many non-traditional factors for CKD appears VC. The pathogenesis of VC it´s multifactorial and it´s in short terms a change of muscle vessels cells to a bone cell; this transformation it´s close related to Chronic Kidney Disease-Bone Metabolism Disorder (CKD-BMD), Vitamin D, phosphorus, calcium and parathyroid hormone are close related to VC. The diagnosis of VC can be done by different methods from Electron Beam Computed Tomography to plain X ray studies; there are many scores base on plain X ray studies that can predict mortality in patients with VC. In our setting there is scarce information regarding VC in dialysis patients, the available information show a higher frequency (~50%) and severe; predictors to the VC in our setting are: age, serum HDL and alkaline phosphatase. It is necessary in the primary care setting the evaluation of VC in order to prevent it appearing. There is not an effective treatment to VC so it´s necessary search for strategies to prevent it.

Downloads

Download data is not yet available.

References

U.S. Renal Data System. USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Bethesda, MD: 2013.

 

Foley R, Parfrey P, Sanark M. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32(Supp 3):S112-9.

 

Parfrey PS, Foley RN. The clinical epidemiology of cardiac disease in chronic renal failure. J Am Soc Nephrol. 1999;10:1606–15.

 

Sud M, Tangri N, Pintilie M, Levey AS, Naimark D. Risk of end-stage renal disease and death after cardiovascular events in chronic kidney disease. Circulation. 2014;130:458-65.

 

Ibels LS, Alfrey AC, Huffer WE, Craswell PW, Anderson JT, Weil R. Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med. 1979;66:790-6.

 

Adragao T, Pires A, Lucas C, Birne R, Magalhaes L, Gonçalves M et al. A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients. Nephrol Dial Transplant. 2004;19:1480-8.

 

Adragao T, Pires A, Birne R, Curto JD, Lucas C, Gonçalves M et al. A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients. Nephrol Dial Transplant. 2009;24:997-1002.

 

Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res. 2004;95:560-7.

 

Liberman M, Pesaro AEP, Carmo LS. Vascular calcification: Pathophysiology and clinical implications. Einstein. 2013;11(3):376-82.

 

SLANH. Guías de práctica clínica para la prevención, diagnóstico, evaluación y tratamiento de los trastornos minerales y óseos en la enfermedad renal crónica (TMO-ERC) en adultos. Nefrologia. 2013;33(1):1-28.

 

Tonelli M, Pannu N, Manns B. Oral phosphate binders in patients  with kidney failure. N Engl J Med. 2010;362:1312-24.

 

Razzaque MS. FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player? Am J Physiol Renal Physiol. 2009;296(3):F470-F6.

 

West SL, Swan VJD, Jamal SA. Effects of calcium on cardiovascular events in patients with kidney disease and in a healthy population. Clin J Am Soc Nephrol. 2010;5:S41–S7.

 

Cannata-Andía JB, Rodríguez-García M, Carrillo-López N, Naves-Díaz M, Díaz-López B. Vascular calcifications: Pathogenesis, management and impact on clinical outcomes. J Am Soc Nephrol. 2006;17:S267-S73.

 

Karohl C, Gascón LDM, Raggi P. Non-invasive imaging for assessment of calcification in chronic kidney disease. Nat Rev Nephrol. 2011; 7:567-77.

 

Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP, Wilson PWF. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis. 1997;132:245-50.

 

Wilson PWF, Kauppila LI, O’Donnell CJ, Kiel DP, Hannan M, Polak JM et al. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001;103:1529-34.

 

Bellasi A, Ferramosca E, Muntner P, Ratti C, Wildman R, Block G et al. Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients Kidney International. 2006;70:1623-8.

 

Sellares VL, Torregrosa V. Alteraciones del metabolismo mineral en la enfermedad renal crónica estadios III, IV y V (no en diálisis). Guías SEN. Nefrología. 2008;3:67-78.

 

Rojas-Campos E, Herrera-Llamas R, Montañez-Fernández JL, Martínez-Martínez P, Andrade-Sierra J, Avila-Baray ÁA et al. Vascular calcification in Mexican hemodialysis patients. Archives of Medical Research. 2013;44:628-32.

 

Abundis-Jiménez JR. Prevalencia de calcificación vascular en pacientes con insuficiencia renal crónica terminal con tratamiento sustitutivo de la función renal en población del Centro Médico Nacional de Occidente [Tesis]. Guadalajara, Jalisco: Universidad de Guadalajara; 2014.

 

Nitta K. Clinical assessment and management of dyslipidemia in patients with chronic kidney disease. Clin Exp Nephrol. 2012;16:522-9.

 

National Kidney Foundation. K/DOQI Clinical practice guidelines for managing dyslipidemias in chronic kidney disease. Am J Kidney Dis. 2003;41(4 (Suppl 3)):S1-S91.

 

Drüeke TB, Massy ZA. Role of vitamin D in vascular calcification: bad guy or good guy? Nephrol Dial Transplant. 2012;27:1704-7

 

Ávila-Díaz M, Mora-Villalpando C, Prado-Uribe MdC, Orihuela-Rodriguez O, Villegas-Antelo E, Gómez-Noriega AM et al. De novo development of heart valve calcification in incident peritoneal dialysis patients. Archives of Medical Research. 2013;44:638-44.

 

Cueto-Manzano AM, Cortes-Sanabria L, Martinez-Ramirez HR, Rojas-Campos E, Barragan G, Alfaro G et al. Detection of early nephropathy in Mexican patients with type 2 diabetes mellitus. Kidney International. 2005;68(97):S40-S5.

 

Méndez-Durán A, Méndez-Bueno JF, Tapia-Yáñez T, Muñoz-Montes A, Aguilar-Sánchez L. Epidemiología de la insuficiencia renal crónica en México. Dial Traspl. 2010;31(1):7-11.

 

López-Leal J, Cortés-Sanabria L, Bañuelos-Chávez KV, Téllez-Agraz EU, Cueto-Manzano A, editores. Prevalencia de nefropatía temprana en pacientes con hipertensión arterial sistémica y factores asociados en primer nivel de atención de la zona metropolitana de Guadalajara, IMSS. En: Memorias LXIII Reunión Anual, 3-6 de diciembre 2014; Cancún, Quintana Roo: Instituto Mexicano de Investigaciones Nefrologicas; 2014.

Published

2018-07-16

Issue

Section

Original Articles