About possible medications to treat SARS-CoV-2 infection, which causes COVID-19: is there any hope?

Authors

  • Javier Torres-López <p>Instituto Mexicano del Seguro Social, Centro M&eacute;dico Nacional Siglo XXI, Hospital de Pediatr&iacute;a &ldquo;Dr. Silvestre Frenk Freund&rdquo;, Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Infecciosas y Parasitarias. Ciudad de M&eacute;xico</p>

DOI:

https://doi.org/10.24875/RMIMSS.M20000023

Keywords:

SARS-CoV-2 Virus, Coronavirus Infections, Therapeutics, Pandemics

Abstract

To date, there is no treatment for patients infected with SARS-CoV-2. Several studies are being carried out in several countries and some have yielded promising results; however, still no effective treatment has been identified to combat COVID-19, one of the most serious threats humanity has suffered in the last 100 years.

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References

Cao B, Wang Y, D, Liu W, Wang J, Fan G, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787-99. doi:10.1056/NEJMoa2001282

 

Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YSE, et al. Small molecules targeting severe acute respiratory syndrome human coronavirus. PNAS. 2004;101(27):10012-7. doi:10.1073/pnas.0403596101

 

Chan JF, Yao Y, Yeung ML, Deng W, Bao L, Jia L, et al. Treatment with lopinavir/ritonavir or interferon-b1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset. J Infect Dis. 2015;212(12):1904-13. doi:10.1093/infdis/jiv392

 

Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mahile M. Hydroxychloroquine and azithromycin as a treatment of COVID-19:results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi:10.1016/j.ijantimicag.2020.105949. Epub 2020 Mar 20.

 

Gao J, Tian Z, Yang X. Breakthrough:chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. BioScience Trends. 2020;14(1):72-3. doi:10.5582/bst.2020.01047

 

Boulware D. Post-exposure prophylaxis/preemptive therapy for SARS-coronavirus-2 (COVID-19 PEP). Minneapolis, MN:University of Minnesota;2020. Disponible en:https://clinicaltrials.gov/ct2/show/NCT04308668?cond=Coronavirus&cntry=US&state=US%3AMN&draw=2&rank=1

 

Dalgard O. Norwegian Coronavirus Disease 2019 Study (NO COVID-19). Akhershus, Norway:Akerhus University Hospital;2019. Disponible en:https://clinicaltrials.gov/ct2/show/NCT04316377?term=chloroquine+and+covid-19&draw=2&rank=3.

 

Schilling W. Chloroquine/hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting (COPCOV). Oxford, UK:University of Oxford;2020. Disponible en:https://clinicaltrials.gov/ct2/show/NCT04303507?term=chloroquine+and+covid-19&draw=2&rank=1

 

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269-71.

 

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016;113(50):14408-13.

 

Madrid PB, Panchal RG, Warren TK, Shurtleft AC, Endsley AN, Green CE, et al. Evaluation of Ebola virus inhibitors for drug repurposing. ACS Infect Dis. 2015;1(7):317-26. doi:10.1021/acsinfecdis.5b00030

Published

2021-07-30

Issue

Section

Editorial