Sensitivity pattern of E. coli at the Bajío National Medical Center
Main Article Content
Keywords
Anti-Infective Agents, Antimicrobial Susceptibility, Escherichia coli
Abstract
Background: Antimicrobial resistance represents a serious public health problem that has caused an increase in the morbidity and mortality of infections, a greater use of antibiotics and excessive hospitalization costs.
Objective: To describe the frequency of Escherichia coli and its pattern of bacterial susceptibility in cultures of blood, urine and other body fluids in a tertiary care hospital.
Material and methods: A quantitative and retrospective test was designed to evaluate the sensitivity pattern of the data obtained in the Microbiology Department. Descriptive statistics were obtained from the sensitivity patterns of the microorganism studied in the period of time analyzed.
Results: The sensitivity pattern of different samples evaluated in the unit (n = 694) was recovered. In the strains analyzed, it was found that about 50% have a positive phenotype for extended-spectrum beta-lactamases and that the sensitivity pattern shows that penicillins, cephalosporins and fluoroquinolones are not adequate antimicrobials to treat infections derived from this microorganism.
Conclusions: The antimicrobial pattern obtained demonstrates the imperative need for rational and well-founded use of antibiotic therapy, highlighted by the great difference with reports in other scientific articles. Investment in mechanisms to confirm these patterns is necessary, which is why no expense should be spared for the identification, typification and classification of disease-causing microorganisms.
References
Hernández-Álvarez E. “Escherichia coli” Productores de BLEE aislados de urocultivo: implicaciones en el diagnóstico y tratamiento de la infección urinaria [tesis de doctorado]. Madrid, España: Universidad Complutense de Madrid; 2010.
Kaper J, Nataro J, Mobley H. Pathogenic Escherichia coli. Nat Rev Microbiol. 2004;2(2):123-40. doi: 10.1038/nrmicro818.
Torres A, Arenas-Hernández M, Martínez-Laguna. Pathogenic Escherichia coli in Latin American. 1st ed. USA: Bentham Ebooks; 2010. doi: 10.2174/97816080519221100101.
Garza-González E, Franco-Cendejas R, Morfín-Otero R, Echaniz-Aviles G, Rojas-Larios F, Bocanegra-Ibarias P, et al. The evolution of Antimicrobial Resistance in Mexico During the Last Decade: Results from the INFAVIR Group. Micro Drug Res, 2020;0(0):1-11. doi: 10.1089/mdr.2019.0354.
Bertrand X, Dowzicky M. Antimicrobial Susceptibility Among Antimicrobial Susceptibility Among Gram-Negative Isolates Collected From Intensive Care Units in North America, Europe, the Asia-Pacific Rim, Latin America, the Middle East, and Africa Between 2004 and 2009 as Part of the Tigecycline Evaluation and Surveillance Trial. Clin Thera. 2011;34(1):124-37. doi: 10.1016/j.clinthera.2011.11.023.
Sidjabat H, Paterson D. Multidrug-resistant Escherichia coli in Asia: epidemiology and management. Exp Rev Anti-Infect Therp. 2015;13(5):575-91. doi: 10.1586/14787210.2015.1028365.
Alós J. Epidemiología y etiología de la infección urinaria comunitaria. Sensibilidad antimicrobiana de los principales patógenos y significado clínico de la resistencia. Enferm Infecc Microbiol Clin. 2005;23(4):3-8.
Bou-Antoun S, Davies J, Guy R, Johnson AP, Sheridan EA, Hope RJ. Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014. Euro Surveill, 2016;21(35):30329. doi: 10.2807/1560-7917. ES.2016.21.35.30329.
Zboromyrska Y, de Cueto López M, Alonso-Tarrés C. Diagnóstico microbiológico de las infecciones del tracto urinario. Soc Esp Enf Infecc. 2019;14:1-7.
Guna Serrano MR, Larrosa Escartín N, Marín Arriazac M, Rodríguez Díaz JC. Diagnóstico microbiológico de la bacteriemia y la fungemia: hemocultivos y métodos moleculares. Enferm Infecc Microbiol Clin. 2019;37(5):335-40. doi: 10.1016/j. eimc.2018.03.005.
López B, Alcázar V, Castellanos M. Vigilancia institucional de la susceptibilidad antimicrobiana en patógenos de interés clínico. Bol Med Hosp Infant Mex. 2013;70:222-9.
Cornejo-Juárez P, Velásquez-Acosta C, Sandoval S, Gordillo P. Patrones de resistencia bacteriana en urocultivos en un hospital oncológico. Salud Publica Mex. 2007;49:330-6.
Salame-Khouri L, Contreras-Pichardo B, Arias-Rodríguez S, Mondragón-Soto M, Cataneo Serrato JL, Núñez Martínez M et al. Epidemiología de las bacteriemias por Escherichia coli en dos hospitales de tercer nivel de la Ciudad de México. An Med. 2018;63:91-5.
Ferreras-Amez JM, Arribas-Entrala B, Aspiroz C, Ezpeleta-Galindo A, Boned-Juliani B. Emergencias (Sant Vicenç dels Horts). 2019;31(6):399-403.
Rendón-Medina MA, Reyes-Arcos A, Rosas-Bello JB, Rodríguez-Weber F. Infecciones de vías urinarias. Patrón de resistencia in vitro de E. coli y E. coli ESBL a quinolonas, trimetoprima-sulfametoxazol y nitrofurantoína. Med Int Mex 2012;28:434-9.
García A, García E, Hernández A. Bacteriemias por Escherichia coli productor de betalactamasas de espectro extendido (BLEE): significación clínica y perspectivas actuales. Rev Esp Quimioter. 2011; 24(2):57-66.
Peralta G, Lamelo M, Alvarez-García P, Velasco M, Delgado A, Horcajada JP, et al. Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. bacteremia. A multicentric cohort study. BMC Infec Dis. 2012;12:245.
Galindo M. Caracterización molecular y patrón de susceptibilidad antimicrobiana de Escherichia coli productora de β-lactamasas de espectro extendido en infección del tracto urinario adquirida en la comunidad. Rev Chil Infect. 2018;35: 29-35.
Ponce de León S. Estado Actual de la Resistencia Antimicrobiana en México Reporte de los Hospitales de la Red del PUCRA: Resistencia antimicrobiana y Consumo de antibióticos. Ciudad de México: Plan universitario de control de la resistencia antimicrobiana; agosto de 2018.
Diagnóstico y Tratamiento de la Infección Aguda, no Complicada del Tracto Urinario en la Mujer. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México: Instituto Mexicano del Seguro Social; 2009. Disponible en: https:// www.imss.gob.mx/sites/all/statics/guiasclinicas/077GER.pdf.
Tao X, Wang H, Min C. A retrospective study on Escherichia coli bacteremia in immunocompromised patients: Microbiological features, clinical characteristics, and risk factors for shock and death. J Clin Lab Anal. 2020;34:23319.
Sader H, Farrell D, Flamm R, Jones R. Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals (2009–2011). Diagn Microbiol Infect Dis. 2014; 78(4):443-8. doi: 10.1016/j.diagmicrobio.2013.11.025.
Ny S, Edquist P, Dumpis U, Gröndahl-Yli-Hannuksela K, Hermes J, Kling AM, et al. Antimicrobial resistance of Escherichia coli isolates from outpatient urinary tract infections in women in six European countries including Russia. J Glob Antimicrob Resist. 2019;17:25-34. doi: 10.1016/j.jgar.2018.11.004.
Sánchez M, Moreno L, Simón J. Resistencias bacterianas en pacientes con bacteriemia. Experiencia de ocho años. An Med (Mex). 2010;55(2):79-84.
Perianes-Díaz ME, Novo-Veleiro I, Solís-Díaz K, Prolo-Acosta A, García-García, I, Alonso-Claudio G. Bacteriemia por Escherichia coli y Klebsiella pneumoniae productoras de betalactamasas de espectro extendido: factores asociados a mortalidad y reingreso hospitalario. Med Clin (Barc). 2014; 142(9):381-6.
Joshi S, Ghole V, Niphadkar K. Neonatal Gram-Negative Bacteremia. Ind Journ Ped. 2000;67:27-32.
De Kraker M, Davey G, Grundmann H; BURDEN study group. Mortality and Hospital Stay Associated with Resistant Staphylococcus aureus and Escherichia coli Bacteremia: Estimating the Burden of Antibiotic Resistance in Europe. PLoS Med. 2011;8(10):e1001104. doi: 10.1371/journal.pmed.1001104
Naquid A, Batalay A, Hussein N, Saeed KA, Ahmed HA, Yousif SH. Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Various Clinical Samples in Duhok City, Kurdistan Region of Iraq. Int J Infect. 2020;7(3):e103740. doi: 10.5812/iji.103740.
Adrianzén D, Arbizu A, Ortiz J, Samalvides F. Mortalidad por bacteriemia causada por Escherichia coli y Klebsiella spp., productoras de betalactamasas de espectro extendido: cohorte retrospectiva en un hospital de Lima, Perú. Rev Peru Med Exp. 2013;30:18-25.
Zhu M, Jin Y, Duan Y, He M, Lin Z, Lin J. Multi-Drug Resistant Escherichia coli Causing Early-Onset Neonatal Sepsis – a Single Center Experience from China. Infect Drug Resist. 2019;12:3695-702. doi: http://doi.org/10.2147/IDR.S229799.
Lai J, Zhu Y, Tang L, Xinzhu L. Epidemiology and antimicrobial susceptibility of invasive Escherichia coli infection in neonates from 2012 to 2019 in Xiamen, China. BMC Infectious Diseases. 2021;21:295. doi: https://doi.org/10.1186/ s12879-021-05981-4 32.
Malhotra R, Sikka R, Chaudhary U. Antimicrobial sensitivity pattern among clinical isolates of Escherichia coli in tertiary care centre of Northern India. Int J Res Med Sci. 2016; 4(2):639- 42. doi http://dx.doi.org/10.18203/2320-6012.ijrms20160330.
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