Atypical clinical presentation of flavivirus. Case report

Main Article Content

Rodrigo Gopar-Nieto
Nancy Libertad Chávez-Gómez
María Elisa González-Rentería
Luis Adrián Estrada-Loyo
Roberto de Jesús García-Avilés
Carlos Lenin Pliego-Reyes

Keywords

Pneumonia, Alphavirus Infections, Chikungunya Virus

Abstract

The first report of chikungunya virus (CHIKV) in Mexico was in may 2014, in Jalisco, and has disseminated along the country in such a way that now is considered a relevant emergent vector-transmitted infection. It is clinically diagnosed by abrupt onset fever, asthenia, arthralgias, myalgias, headache and rash. In the clinical case, we described a women from Guerrero that had pulmonary symptomatology associated to CHIKV, which is an atypical clinical presentation that has been reported only in a hundred cases worldwide. In the epidemiological context the only known tool that we have to prevent the disease is the eradication of vectors because we lack population immunity, thus the importance of avoiding water accumulation and using protective gear. In Mexico we are acting through media advertisements in order to avoid, in first place the acute infection, which in severe cases can cause death, and in second place the chronic complications.

Abstract 204 | PDF (Spanish) Downloads 82 PubMed (Spanish) Downloads 0

References

Martínez-Sánchez A, Martínez-Ramos EB, Chávez-Ángeles MG. Panorama situacional de México ante la pandemia del virus chikunguña. Rev Med Inst Mex Seguro Soc. 2015;53(2):200-5.

 

Barrera-Cruz A, Díaz-Ramos RD, Viniegra-Osorio A, Grajales-Muñiz C, Dávila-Torres J. Lineamientos técnicos para la prevención y el tratamiento de la fiebre chikunguña. Rev Med Inst Mex Seguro Soc. 2015;53(1):102-19.

 

Del Carpio-Orantes L. Arbovirus emergentes en México: chikunguña y zika. Rev Med Inst Mex Seguro Soc. 2016;54(3):278-9.

 

Powers AM, Logue CH. Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol. 2007;88:2363-77.

 

Kucharz EJ, Cebula-Byrska I. Chikungunya fever. European Journal of Internal Medicine. 2012;23:325-329.

 

Morens DM, Fauci AS. Chikungunya at the door— Déjà vu all over again? N Engl J Med. 2014;371(10):885-7.

 

Staples JE, Fischer M. Chikungunya virus in the Americas— What a vectorborne pathogen can do. N Engl J Med. 2014;371(10):887-9.

 

Rivera-Ávila RC. Fiebre chikungunya en México: caso confirmado y apuntes para la respuesta epidemiológica. Salud Pública Méx. 2014;56(4):402-4.

 

Lum FM, Teo TH, Lee WW, Kam YW, Renia L, Ng LF. An essential role of antibodies in the control of Chikungunya virus infection. J Immunol. 2013;190(12):6295-302.

 

Bernard E, Solignat M, Gay B, Chazal N, Higgs S, Devaux C. Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments. PLoS One. 2010;5(7):e11479.

 

Petitdemange C, Wauquier N, Vieillard V. Control of immunopathology during chikungunya virus infection. J Allergy Clin Immunol. 2015;135(4):846-855.

 

Wauquier N, Becquart P, Nkoghe D, Padilla C, Ndjoyi-Mbiguino A, Leroy A. The acute phase of chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J Infect Dis. 2011;204:115-23.

 

Horau JJ, Jaffar Bandjee MC, Krejbich Trotot P, Das T, Li-Pat-Yuen G, Dassa B, et al. Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol. 2010;184:5914-27.

 

Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Negl Trop Dis. 2013;7(1):e2004.

 

Torres JR, Córdova L, Castro JS, Rodríguez L, Saravia V, Arvelaez J, et al. Chikungunya fever: atypical and lethal cases in the Western hemisphere. IDCases. 2015;2:6-10.

 

Rajapakse S, Rodrigo C, Rajapakse A. Atypical manifestations of chikungunya infection. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010;104:89-96.

 

Staikowsky F, Talarmin F, Grivard P, Souab A, Schuffenecker I, Le Roux K, et al. Prospective study of Chikungunya virus acute infection in the Island of La Réunion during the 2005-2006 outbreak. PLoS One. 2009;4(10):e7603.

 

Petersen LR, Powers AM. Chikungunya: epidemiology. F1000Res. 2016;19(5). DOI: 10.12688/f1000research.7171.1. eCollection 2016.

 

Weaver SC, Osorio JE, Livengood JA, Chen R, Stinchcomb DT. Chikungunya virus and prospects for a vaccine. Expert Rev Vaccines. 2012;11:1087-101.

 

Economopoulou A, Domínguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, et al. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiol Infect. 2009;137:534-541.