Human platelet antigen: brief review of the topic and its clinical significance

Authors

  • Mari C. Moran-Espinosa <p>Secretar&iacute;a de Salud, Hospital Infantil de M&eacute;xico Federico G&oacute;mez, Centro de Investigaci&oacute;n en Malformaciones Cong&eacute;nitas.&nbsp;Ciudad de M&eacute;xico, M&eacute;xico.</p> http://orcid.org/0000-0002-1946-0790
  • Stella A. Zepeda-Aguilera <p>Secretar&iacute;a de Salud, Hospital Infantil de M&eacute;xico Federico G&oacute;mez, Centro de Investigaci&oacute;n en Malformaciones Cong&eacute;nitas.&nbsp;Ciudad de M&eacute;xico, M&eacute;xico.</p> http://orcid.org/0009-0007-2467-2302
  • Hector Diaz-Garcia <p>Instituto Polit&eacute;cnico Nacional, Escuela Superior de Enfermer&iacute;a y Obstetricia. Ciudad de M&eacute;xico, M&eacute;xico.</p> http://orcid.org/0000-0002-2375-4759

DOI:

https://doi.org/10.5281/zenodo.10790529

Keywords:

Platelet Transfusion, Thrombocytopenia, Human Platelet, Antigens, Blood Platelets

Abstract

Platelet antigens are essential cellular components in the coagulation cascade and the immune response. Platelets are small anucleate cellular-fragments, measuring 2 to 3 ìm, resulting from the fragmentation of megakaryocyte cytoplasm. Their role in hemostasis involves clot formation to halt bleeding in case of vascular injuries. Platelet antigens are proteins found on the surface of these cell fragments, participating in interactions with other blood cells and the immune response. Genetic variability and individual differences in antigens have led to the discovery of various antigen systems, such as the HLA (human leukocyte antigen) system and the ABO system. These systems influence blood compatibility in transfusions and transplants, as well as the occurrence of adverse reactions. Research in this field has proposed mechanisms related to the pathogenesis of platelet disorders and autoimmune diseases. The study of antigens has evolved with advances in genetics, molecular biology, and immunology, leading to a better understanding of their clinical relevance and impact on human health. The identification of these antigens remains crucial for improving transfusion therapies, investigating bleeding disorders, and exploring potential therapeutic targets in various diseases.

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Author Biographies

  • Mari C. Moran-Espinosa, <p>Secretar&iacute;a de Salud, Hospital Infantil de M&eacute;xico Federico G&oacute;mez, Centro de Investigaci&oacute;n en Malformaciones Cong&eacute;nitas.&nbsp;Ciudad de M&eacute;xico, M&eacute;xico.</p>

    Facultad de Química, Universidad Nacional Autónoma de México, Doctorado en Investigación Clínica Experimental en salud. (2022-)

    Hospital Infantil de México Federico Gómez, Unidad de Hemato-Oncología e Investigación, Centro de Investigación en Malformaciones Congénitas. (2020-)

    Hospital Infantil de México Federico Gómez. Laboratorio Clínico. Cofundadora del Laboratorio de Histocompatibilidad (2015).

    Facultad de Química, Universidad Nacional Autónoma de México. Maestría en Investigación Clínica Experimental en Salud.

    Facultad de Química, Universidad Nacional Autónoma de México. Licenciatura en Química Farmacéutica Biológica.

  • Stella A. Zepeda-Aguilera, <p>Secretar&iacute;a de Salud, Hospital Infantil de M&eacute;xico Federico G&oacute;mez, Centro de Investigaci&oacute;n en Malformaciones Cong&eacute;nitas.&nbsp;Ciudad de M&eacute;xico, M&eacute;xico.</p>

    Escuela Superior de Medicina. Instituto Politécnico Nacional. Médico cirujano y Partero (2017-2022)

    Hospital General de la Villa. Secretaria de Salud. Médico Interno de Pregrado (2022-2023).

    Hospital Infantil de México Federico Gómez, Unidad de Hemato-Oncología e Investigación, Centro de Malformaciones Congénitas y Unidad de Neonatología. Secretaria de Salud. Médico Pasante en Servicio Social en Investigación (2023-2024).

  • Hector Diaz-Garcia, <p>Instituto Polit&eacute;cnico Nacional, Escuela Superior de Enfermer&iacute;a y Obstetricia. Ciudad de M&eacute;xico, M&eacute;xico.</p>

    Escuela Superior de Enfermería y Obstetricia, Instituto Politécnico Nacional. Profesor de Asignatura. (2022-)

    CONAHCyT. Sede: Hospital Infantil de México Federico Gómez. Investigador Asociado. (julio-noviembre de 2022 y julio-septiembre de 2023)

    Hospital Infantil de México Federico Gómez. Unidad de Hemato-Oncología e Investigación. Centro de Investigación en Malformaciones Congénitas. Investigador Invitado (2021-).

    Wake Forest Institute for Regenerative Medicine, North Carolina, USA. Estancia de Investigación (2017).

    Hospital Infantil de México Federico Gómez. Unidad de Hemato-Oncología e Investigación. Centro de Investigación en Malformaciones Congénitas. Estancia de Investigación (2016-2017).

    Escuela Superior de Medicina. Instituto Politécnico Nacional. Doctorado en Investigación en Medicina.

    Escuela Superior de Medicina. Instituto Politécnico Nacional. Maestría en Ciencias de la Salud.

    Escuela Superior de Enfermería y Obstetricia. Instituto Politécnico Nacional. Licenciatura en Enfermería.

    https://scholar.google.com.mx/citations?user=Cft-MA8AAAAJ&hl=es.

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Published

2024-05-20

Issue

Vol. 62 No. Suplemento 1 (2024): Banco de Sangre

Section

Review Article

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