Emerging roles of neutrophils in the prognosis of colorectal cancer

Authors

  • Alejandra Mantilla <p>Instituto Mexicano del Seguro Social. Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Departamento de Patolog&iacute;a. Ciudad de M&eacute;xico. M&eacute;xico.&nbsp;</p> http://orcid.org/0000-0002-5085-6216
  • María de Lourdes Ramírez-Ramírez <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Departamento de Colon y Recto. Ciudad de M&eacute;xico. M&eacute;xico.</p> http://orcid.org/0009-0003-1720-3904
  • Antonio Jorge Berlanga-Taylor <p>Imperial College London,&nbsp;Department of Epidemiology and Biostatistics. Londres. Inglaterra.</p> http://orcid.org/0000-0002-4199-7332
  • Eduardo Vadillo <p>Instituto Mexicano del Seguro Social, Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Oncol&oacute;gicas. Ciudad de M&eacute;xico. M&eacute;xico.</p> http://orcid.org/0000-0001-5939-8031

DOI:

https://doi.org/10.5281/zenodo.13306792

Keywords:

Biomarcadores de Tumor, Neoplasias del Colon, Neutrófilos, Fenotipo, Microambiente Tumoral / Biomarkers, Tumor, Colonic Neoplasms, Neutrophils, Phenotype, Tumor Microenvironmen

Abstract

Colorectal cancer (CRC) is one of the most frequent and lethal cancers in Mexico and the world. It is noteworthy that globally, the incidence of CRC is increasing at a rate of 2% per year in patients younger than 50 years of age. Its early detection, primarily based on colonoscopy screening starting at 45 years of age, is an essential weapon to reduce its mortality. When CRC is detected, the treatment is surgical; however, the pathology reports and biomedical research on the tumor microenvironment may offer new parameters that could serve as prognostic biomarkers. In this respect, the presence or absence of neutrophils associated with neoplastic tissues may indicate their prognostic relevance for the disease. Although this field is still controversial, our recently published evidence suggests that the presence of neutrophils with an anti-tumoral phenotype, particularly at the invasive margin of the colon tumors, could indicate a favorable prognosis. This emerging information suggests that the characterization of immune cells, particularly neutrophils, could contribute to assessing the evolution of CRC and identifying patients at increased risk of recurrences. In this article, we discuss relevant points that should be addressed when interpreting neutrophil-related data in the context of CRC.

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Author Biographies

  • Alejandra Mantilla, <p>Instituto Mexicano del Seguro Social. Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Departamento de Patolog&iacute;a. Ciudad de M&eacute;xico. M&eacute;xico.&nbsp;</p>

    Centro Médico Nacional Siglo XXI. Hospital de Oncología. Departamento de Patología. Medica Patóloga. 

  • María de Lourdes Ramírez-Ramírez, <p>Instituto Mexicano del Seguro Social,&nbsp;Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Departamento de Colon y Recto. Ciudad de M&eacute;xico. M&eacute;xico.</p>

    Centro Médico Nacional Siglo XXI. Hospital de Oncología. Departamento de Colon y Recto. Cirujana de colon y recto. 

  • Antonio Jorge Berlanga-Taylor, <p>Imperial College London,&nbsp;Department of Epidemiology and Biostatistics. Londres. Inglaterra.</p>

    Invetigador Asociado.

  • Eduardo Vadillo, <p>Instituto Mexicano del Seguro Social, Centro M&eacute;dico Nacional Siglo XXI,&nbsp;Hospital de Oncolog&iacute;a,&nbsp;Unidad de Investigaci&oacute;n M&eacute;dica en Enfermedades Oncol&oacute;gicas. Ciudad de M&eacute;xico. M&eacute;xico.</p>

    Realizó sus estudios de Maestría y Doctorado en el Laboratorio de Linfopoyesis de la Dra. Rosana Pelayo del 2008-2015. Durante este periodo se enfocó al estudio del desarrollo de células NK en condiciones de inflamación y leucemia. Después, realizó una estancia postdoctoral (2 años) en el Departamento de Biomedicina Molecular del Cinvestav Zacatenco en el Laboratorio del Dr. Michael Schnoor en donde estudio los patrones de migración de leucocitos normales y leucémicos. Realizó una segunda estancia postdoctoral (2 años) en la Universitätsklinikum Münster Alemania en el Laboratorio de Adhesión Leucocitaria del Dr. Alexander Zarbock, en donde profundizó en los mecanismos involucrados en la diapedesis de los neutrófilos. Actualmente está adscrito a la Unidad de Investigación Médica en Enfermedades Oncológicas (UIMEO) en el Laboratorio de Migración y Metástasis. Sus objetivos científicos están enfocados a estudiar el papel de los neutrófilos en la progresión tumoral de distintos tumores sólidos. Cuenta con la distinción de Investigador Nacional Nivel 1.

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Published

2024-10-29 — Updated on 2025-06-16

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Vol. 62 No. 6 (2024): November-December

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