Erythrocyte morphological alterations as predictors of kidney injury severity
DOI:
https://doi.org/10.5281/zenodo.13306729Keywords:
Tasa de Filtración Glomerular, Índices de Eritrocitos, Eritrocitos Anormales, Insuficiencia Renal Crónica / Glomerular Filtration Rate, Erythrocyte Indices, Erythrocytes, Abnormal, Renal Insufficiency, ChronicAbstract
Background: Chronic kidney disease (CKD) is characterized by decreased renal function. Detecting and treating CKD in its early stages is essential for prognosis and use of less invasive renal treatments. CKD can manifest with different markers of renal damage. However, few studies evaluate the presence of erythrocyte morphological changes in the peripheral blood of patients with CKD.
Objective: To evaluate the correlation between erythrocyte morphological changes and KDIGO stage as a predictor of the severity of renal damage.
Material and methods: A descriptive, prospective, crosssectional, and correlational study of patients admitted between March and April 2023. Qualitative variables were reported as frequencies and percentages, and quantitative variables were reported by central tendency and dispersion measures. Finally, Spearman correlation was performed between erythrocyte morphological alterations and the KDIGO stage in patients with CKD.
Results: A total of 385 patients were included, and the correlation of the number of erythrocyte morphological alterations with the KDIGO stage showed that it is directly proportional in a significant way (Spearman’s ρ 0.489, p < 0.0001). It was higher for anisocytosis.
Conclusions: Erythrocyte morphological alterations in patients with CKD are frequent and could be a predictor of the severity of this disease.
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de las Cuevas Allende R, Díaz de Entresotos L, Conde Díez S. Anaemia of chronic diseases: Pathophysiology, diagnosis and treatment. Med Clin (Barc). 2021;156(5):235-42.
García-Maset R, Bover J, Segura-de la Morena J, et al. Information and consensus document for the detection and management of chronic kidney disease. Nefrología. 2022;42(3): 233-64.
Tratamiento de la ENFERMEDAD ALZHEIMER Evidencias Recomendaciones D DE. GUÍA DE PRÁCTICA CLÍNICA GPC. 2017 [cited 2024 Mar 4]; Available from: http://www.imss. gob.mx/profesionales-salud/gpc.
Raman M, Middleton RJ, Kalra PA, et al. Estimating renal function in old people: an in-depth review. Int Urol Nephrol. 2017;49 (11):1979.
Heras-Benito M. Renal anemia: current treatments and emerging molecules. Revista Clínica Española (English Edition). 2023;223(7):433-9.
Habib A, Ahmad R, Rehman S. Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters. Int J Res Med Sci. 2017;5(11):4998-5003.
Revin V V, Ushakova AA, Gromova NV, et al. Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen- Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases. Advances in Hepatology. 2017;8964587.
Thompson AA, Cornelius AS, Asakura T, et al. COMPARATIVE STUDIES OF PHENOTHIAZINE DERIVATIVES FOR THEIR EFFECTS ON SWELLING OF NORMAL AND SICKLE ERYTHROCYTES. Gen Pharmac. 1993;24(4):3992.
Brun JF, Varlet-Marie E, Myzia J, et al. Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis. Metabolites 2022;12(1):4.
Bateman RM, Sharpe MD, Singer M, et al. The Effect of Sepsis on the Erythrocyte. Int J Mol Sci. 2017;18(9).
Montoya-Navarrete AL, Guerrero-Barrera AL, Quezada-Tristán T, et al. Red blood cells morphology and morphometry in adult, senior, and geriatricians dogs by optical and scanning electron microscopy. Front Vet Sci. 2022;9.
El-Haj N, Harn-Enz Z, Singer ST, et al. From microcytosis to macrodiagnosis. Pediatrics. 2021;148(2).
Terry LRN, Mendoza-Hernández CA. Importance of peripheral blood smears study in the elderly. Medisur. 2017;15(3):362-382.
Pérez-Mendoza HK, Benavidez-González SJ. Comportamiento hematológico de los eritrocitos en pacientes con Enfermedad Renal Crónica en Hemodiálisis del Centro Nefrológico Cruz Azul-Managua II Semestre del 2019. Tesis. 2021; Universidad Nacional Autónoma de Nicaragua, Managua.
Zhang F, Wang H, Bai Y, et al. Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis. BMC Nephrol. 2023; 24(1).
Bindroo S, Rodriguez BSQ, Challa HJ. Renal Failure. Nutrition Support for the Critically Ill Patient: A Guide to Practice. 2023; 491-504.
Sachdeva B, Zulfiqar H, Aeddula NR. Peritoneal Dialysis. Management of Kidney Diseases. 2023;383-404.
Batchelor EK, Kapitsinou P, Pergola PE, et al. Iron Deficiency in Chronic Kidney Disease: Updates on Pathophysiology, Diagnosis, and Treatment. J Am Soc Nephrol. 2020;31(3):456.
Elliott J. Therapeutics of managing reduced red cell mass associated with chronic kidney disease – Is there a case for earlier intervention? Vol. 46, Journal of Veterinary Pharmacology and Therapeutics. John Wiley and Sons Inc; 2023. p. 145–57.
Sciarra F, Franceschini E, Campolo F, et al. The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? Int J Mol Sci. 2023;24(13).
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