Comment on the article “Erythrocyte morphological alterations as predictors of kidney injury severity”
DOI:
https://doi.org/10.5281/zenodo.15178497Keywords:
Renal Insufficiency, Chronic, Erythrocytes, AnemiaAbstract
After reviewing the article “Erythrocyte morphological alterations as predictors of kidney injury severity” published by Cruz-Balbuena et al., we can emphasize that erythrocytic changes have several pathophysiological mechanisms, such as iron deficiency, vitamin B12 deficiency, and the pro-inflammatory state of chronic kidney disease (CKD) itself. Furthermore, due to the accumulation of uremic toxins that result in a shortened lifespan of erythrocytes, a selection bias was found in their population and a positive but non-linear correlation. There are already several well-established progression markers with better correlation.
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Cruz-Balbuena A, Piedras Reyes L, Sánchez-Serrano JC et al. Alteraciones morfológicas eritrocitarias como predictores de la gravedad del daño renal. Rev Med Inst Mex Seguro Soc. 2024;62(6):e6205. doi: 10.5281/zenodo.13306729
Georgatzakou HT, Antonelou MH, Papassideri IS, et al. Red blood cell abnormalities and the pathogenesis of anemia in end-stage renal disease. Proteomics Clin Appl. 2016;10(8):778-90. doi: 10.1002/prca.201500127
Terry LRN, Mendoza-Hernández CA. Importance of peripheral blood smears study in the elderly. Medisur. 2017;15(3):362-82.
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