Long-term outcomes of maxillectomy for paranasal sinus cancer
Main Article Content
Keywords
Paranasal Sinus Neoplasms, Maxillary Osteotomy, Survivorship, Follow-Up
Abstract
Abstract
Background: Paranasal sinus cancer comprises a group of neoplasms with low incidence but high aggressiveness, due to their anatomical location in the center of the face and the significant sequelae caused by both the disease and its treatment. Surgery for maxillary sinus neoplasms is considered potentially curative in early stages; however, maxillectomy is a procedure that requires a high level of surgical skill and represents a challenge for oncologic surgeons.
Objective: To describe overall survival and the outcomes of surgical treatment based on maxillectomy, either as a standalone procedure or in combination with radiosensitizing chemotherapy and/or radiotherapy, in patients treated between 2013 and 2023 at the High Specialty Medical Unit (UMAE), Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social.
Materials and methods: This was a retrospective longitudinal study with follow-up of a series of cases. Descriptive statistical analysis was performed using SPSS version 29 software. Qualitative variables were reported as proportions and percentages, and quantitative variables as means with standard deviation or medians with interquartile ranges.
Results: The 10-year overall survival rate was 55.3% in patients who underwent surgery. Regarding survival specific to the type of surgical procedure performed, segmental resections offered higher survival rates, reaching 61.5% at 10 years and a median survival of 102 months.
Conclusions: The results of the surgical management show local recurrence rates and overall survival comparable to those described in the international literature.
References
1. Thompson LDR, Bishop JA. Update from the 5th edition of the World Health Organization Classification of Head and neck tumors: Nasal cavity, paranasal sinuses and skull base. Head Neck Pathol [Internet]. 2022;16(1):1–18. Disponible en: http://dx.doi.org/10.1007/s12105-021-01406-5
2. American Society of Clinical Oncology. Nasal Cavity and Paranasal Sinus Cancer Guide. Cancer.Net Editorial Board, 11/2022
3. Tratamiento del cáncer de seno paranasal y de cavidad nasal en adultos. Bethesda, MD: National Cancer Institute. Actualización: . Disponible en: https://www.cancer.gov/espanol/tipos/cabeza-cuello/pro/adulto/tratamiento-seno-paranasal-pdq. Fecha de acceso: 29/04/2024
4. Herrera Gómes. Ángel, Manual de Oncología Procedimientos Médico Quirúrgicos. Editorial, McGraw-Hill. Edición, 7a, 2023. ISBN, 9786071519290
5. Ye Z, Li X, Xie F, Sun J, Yang D, Deng C, et al. A single-cell sequencing-based analysis of a 13-year-old with maxillary sinus NUT carcinoma. Oral Oncol [Internet]. 2025;162(107185):107185. Disponible en: http://dx.doi.org/10.1016/j.oraloncology.2025.107185
6. Chatelet F, Simon F, Bedarida V, Le Clerc N, Adle-Biassette H, Manivet P, Herman P, Verillaud B. Surgical Management of Sinonasal Cancers: A Comprehensive Review. Cancers (Basel). 2021 Aug 8;13(16):3995. doi: 10.3390/cancers13163995. PMID: 34439150; PMCID: PMC8393312
7. Thawani R, Kim MS, Arastu A, Feng Z, The contemporary management of cancers of the sinonasal tract in adults. CA Cancer J Clin. 2023 Jan;73(1):72-112. doi: 10.3322/caac.21752. Epub 2022 Aug 2. PMID: 35916666; PMCID: PMC9840681.
8. Roman Povolotskiy BA, Nicole I. Farber BS, Richard D. Bavier BA, Endoscopic Versus Open Resection of Non-Squamous Cell Carcinoma Sinonasal Malignancies. Laryngoscope, 130: 1872–1876, 2020.
9. Rajendran B. Surgical outcomes of endoscopic versus open resection for the management of sinonasal malignancies. J Korean Assoc Oral Maxillofac Surg. 2020 Dec 31;46(6):373-378. doi: 10.5125/jkaoms.2020.46.6.373. PMID: 33377461
10. Milano AF. Cancer of the Nasal Cavity, middle ear and accessory sinuses - 15 year comparative survival and mortality analysis by age, sex, race, stage, grade, cohort entry time-period, disease duration and topographic primary sites: A systematic review of 13,404 cases for diagnosis years 2000-2017: (NCI SEER*stat 8.3.8). J Insur Med [Internet]. 2024;51(2):77–91. Disponible en: http://dx.doi.org/10.17849/insm-51-2-77-91.1
11. Bertran J, Thomson ACS. Current concepts in head and neck surgery. Vet Clin North Am Small Anim Pract [Internet]. 2022;52(2):489–512. Disponible en: http://dx.doi.org/10.1016/j.cvsm.2021.12.006.
12. Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, et al. The contemporary management of cancers of the sinonasal tract in adults. CA Cancer J Clin [Internet]. 2023;73(1):72–112. Disponible en: http://dx.doi.org/10.3322/caac.21752
13. König J, Kelemen K, Váncsa S, Szabó B, Varga G, Mikulás K, et al. Comparative analysis of surgical and prosthetic rehabilitation in maxillectomy: A systematic review and meta-analysis on quality-of-life scores and objective speech and masticatory measurements. J Prosthet Dent [Internet]. 2025;133(1):305–14. Disponible en: http://dx.doi.org/10.1016/j.prosdent.2023.11.023
14. Chung SY, Halderman AA. Tips and tricks for management of the dysfunctional maxillary sinus. Curr Opin Otolaryngol Head Neck Surg [Internet]. 2023;31(1):24–32. Disponible en: http://dx.doi.org/10.1097/MOO.0000000000000860
15. Taylor MA, Saba NF. Cancer of the paranasal sinuses. Hematol Oncol Clin North Am [Internet]. 2021;35(5):949–62. Disponible en: http://dx.doi.org/10.1016/j.hoc.2021.05.006
16. Kong KA, Thorp BD, Sheth SH. The role of induction therapy for sinonasal cancers. Curr Treat Options Oncol [Internet]. 2023;24(3):162–9. Disponible en: http://dx.doi.org/10.1007/s11864-022-01046-z
17. Nguyen ES, Risbud A, Birkenbeuel JL, Murphy LS, Goshtasbi K, Pang JC, et al. Prognostic factors and outcomes of DE Novo sinonasal squamous cell carcinoma: A systematic review and meta-analysis. Otolaryngol Head Neck Surg [Internet]. 2022;166(3):434–43. Disponible en: http://dx.doi.org/10.1177/01945998211021023
18. Chatelet F, Chevret S, Vinciguerra A, Bertazzoni G, Camous D, Ferrari M, et al. Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base. Eur J Cancer [Internet]. 2025;220(115382):115382. Disponible en: http://dx.doi.org/10.1016/j.ejca.2025.115382
19. Keerio AA, Qayyum MU, Kashif A, Dhanani R, Rashid A, Faisal M, Hussain R, Jamshed A. Treatment Outcomes of Maxillary Sinus Squamous Cell Carcinoma at a Dedicated Cancer Institute: A Retrospective Study. Cureus. 2022 Jun 3;14(6):e25644. doi: 10.7759/cureus.25644. PMID: 35795498; PMCID: PMC925.
20. Iyizoba-Ebozue Z, Fleming JC, Prestwich RJD, Thomson DJ. Management of sinonasal cancers: Survey of UK practice and literature overview. Eur J Surg Oncol [Internet]. 2022;48(1):32–43. Disponible en: http://dx.doi.org/10.1016/j.ejso.2021.11.124
21. Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, et al. High-risk cutaneous squamous cell carcinoma of the head and neck: A clinical review. Ann Surg Oncol [Internet]. 2021;28(13):9009–30. Disponible en: http://dx.doi.org/10.1245/s10434-021-10108-9
22. Over LM, Dierks E. Interdisciplinary prosthetic rehabilitation following bilateral maxillectomy with total upper lip and unilateral zygoma resection: A clinical report. J Prosthet Dent [Internet]. 2024;131(2):341–5. Disponible en: http://dx.doi.org/10.1016/j.prosdent.2022.03.038
23. National Comprehensive Cancer Network. Updates of the NCCN Guidelines for Head and Neck Cancers. Version 4.2024, 5/1/2024
24. J.-P. Machiels, C. René Leemans, W. Golusinski, C. Grau, L. Licitra, V. Gregoire, ya on behalf of the EHNS Executive Board, ESMO Guidelines Committee, ESTRO Head Office. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Published in 2020
25. Keerio AA, Qayyum MU, Kashif A, Dhanani R, Rashid A, Faisal M, Hussain R, Jamshed A. Treatment Outcomes of Maxillary Sinus Squamous Cell Carcinoma at a Dedicated Cancer Institute: A Retrospective Study. Cureus. 2022 Jun 3;14(6):e25644. doi: 10.7759/cureus.25644. PMID: 35795498;
26. Kejner AE, Harris BN, Patel R, McMullen C, Weir J, Dahshan BA, et al. Management of the parotid for high-risk cutaneous squamous cell carcinoma: A review from the salivary section of the American Head and Neck Society. Am J Otolaryngol [Internet]. 2022;43(2):103374. Disponible en: http://dx.doi.org/10.1016/j.amjoto.2022.103374
Article Sidebar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors retain their copyright and grant the Revista Médica del IMSS the right of first publication. Articles are distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows sharing as long as the author and the original source are properly credited.