Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis
Keywords:
Colitis, Ulcerative, Diet, Probiotics, TreatmentAbstract
Background: Probiotics have been used in the adjuvant treatment of Ulcerative Colitis (UC).
Objective: To evaluate the role of a combination of probiotics on the clinical, histological changes and feeding tolerance in patients with UC.
Methods: An open CU patients with mild to moderate activity and clinical trial was conducted. Patients were randomized to receive or a combination of 6 strains of probiotics for 3 months while continuing their drug treatment established. CU activity was assessed by Truelove and Witts scale and histological findings by Gupta index. Descriptive statistics, Chi square test and Student t test for comparison of the two groups was performed.
Results: In each group 17 patients were included. An improvement was found in the disease activity (52.9% vs. 23.5%, p = 0.07) and in histologic index (82.3% vs. 41.1%, p = 0.03) in patients treated with probiotics compared to the control group. Improved food tolerance was also observed in patients treated with probiotics.
Conclusion: The study shows a beneficial short-term effect on symptoms, histological findings and feeding tolerance with the administration of a combination of 6 strains of probiotics in patients with UC.
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