The renin-angiotensin-aldosterone system and its inhibitors in the context of the COVID-19 pandemic
DOI:
https://doi.org/10.24875/RMIMSS.M20000059Keywords:
Coronavirus Infections, Angiotensin-Converting Enzyme Inhibitors, Peptidyl-Dipeptidase A, Renin-Angiotensin System, Receptors, Angiotensin, COVID-19Abstract
One of the confusions aroused by the outbreak of COVID-19 pandemic is the idea that angiotensin converting enzyme inhibitors and type 1 angiotensin II receptor may aggravate the lung damage induced by SARS CoV-2 virus in older adult patients. In this brief statement, the scientific evidence supporting this association is analyzed from a critical perspective.
Downloads
References
Li G, Hu R, Zhang X. Antihypertensive treatment with ACEI/ARB of patients with Covid-19 complicated by hypertension. Hypert Res. 2020;43(6):588-90.
Mourad Jl, Levy BI. Interaction between RAAS inhibitors and ACE2 in the context of COVID-19. Nat Rev Cardiol. 2020;17(5):313.
Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. N Engl J Med. 2020;382(17):1653-9.
Instituto Nacional de Salud, Secretaría de Salud. Encuesta Nacional de Salud y Nutrición de medio camino. 2016. Disponible en:https://www.gob.mx/cms/uploads/attachment/file/209093/ENSANUT.pdf.
Borghi C, Rossi F. Role of the renin-angiotensin-aldosterone system and its pharmacological inhibitors in cardiovascular diseases:complex and critical issues. High Blood Pressure Cardiovasc Prev. 2015;22:429-44.
Lavoie JL, Sigmund CD. Minireview:overview of the renin-angiotensin system. Endocrinology. 2003;144:2179-83.
Miller AJ, Arnold AC. The renin-angiotensin system —an endocrine and paracrine system. Clin Auton Res. 2019;29:231-43.
Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin to angiotensin 1-9. Circ Res. 2000;87:E1-9.
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS Coronavirus-induced lung injury. Nat Med. 2005;11:875-9.
Li W, Moore MJ, Vasileva, Sui J, Wong SK, Berne MA, et al. Angiotensin converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450-4.
Epelman S, Shrestha K, Troughton RW, Francis GS, Sen S, Klein AL, et al. Soluble angiotensin converting enzyme in human heart failure:relation with myocardial function and clinical outcomes. J Card Fail. 2009;15:565-71.
Furihashi M, Moniwa T, Mita T, Fuseya T, Ishimura S, Ohno K, et al. Urinary angiotensin-converting enzyme 2 in hypertensive patients maybe increased by Olmesartan, an angiotensin II receptor blocker. Am J Hypert. 2015;28:15-21.
Downloads
Published
Issue
Section
License
Authors retain their copyright and grant the Revista Médica del IMSS the right of first publication. Articles are distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows sharing as long as the author and the original source are properly credited.