Autoimmune/inflammatory syndrome induced by adjuvants. Case report
Main Article Content
Keywords
Breast Implants, Autoimmune Diseases, Hemophilia A
Abstract
Background: The indiscriminate application of substances for aesthetic purposes, such as silicone in breast implants, leads to the production of common local signs such as inflammation, skin irregularities, edema, erythema, vascular neoformations, and ulcers, which can evolve into general symptoms such as fever, asthenia, weakness, arthralgia or activate the immune system abnormally, causing the appearance of autoimmune diseases. This set of signs and symptoms is called adjuvant-induced autoimmune/inflammatory syndrome.
Clinical case: We present the case of a 50-year-old woman with a history of silicone-based breast implants who spontaneously developed a hemorrhagic coagulopathy, type A acquired hemophilia was documented, that is, autoantibodies against coagulation factor VIII. Thanks to the work of a multidisciplinary team, it is possible to successfully diagnose and treat the patient with bridging agents, implant removal and management of associated symptoms.
Conclusion: The importance of knowing the pathology is recognized, which, although it is rare, when it occurs has a high mortality rate if it is not diagnosed and treated on time.
References
Carbón AMT, Jaramillo MAO, Ruiz DAP. Sustancias adyuvantes y síndrome autoinmune inflamatorio inducido por adyuvantes. Presentación de un caso. Panor Cuba Salud. 25 de octubre de 2019;15(1 (40)):59-64.
Poucel-Sánchez-Medal F, Salomón CMC, Villalpando EV, Salgado JEG. Riego de enferemdades del tejido conectivo en pacientes con implantes mamarios de silicón. Cir Plástica. 2014; 24(2):101-105.
Arias S, Fonsalía V, Casavieja G, Ruiz Díaz E, Chapper C, Magariños A. Inhibidor adquirido del factor VIII en paciente no hemofílico: Caso clínico y actualización. Rev Médica Urug. Diciembre de 2006;22(4):305-10.
Duboscq C, Ceresetto JM, Arias M, Forastiero R. Detección de inhibidor adquirido específico de factor VIII. Acta Bioquím Clín Latinoam. 2016;50(2):223-232.
Torres-Ruíz JJ, Martín-Nares E, López-Íñiguez A . Síndrome autoinmune/autoinflamatorio inducido por adyuvantes (ASIA). Rev Med MD. 2016;7.8(3):170-181.
Síndrome ASIA: prótesis mamarias y enfermedad de Still. Medicina Buenos Aires. 2017;77(5).
Health C for D and R. Breast Implants. FDA; 2021. Disponible en: https://www.fda.gov/medical-devices/implants -and-prosthetics/breast-implants.
Majluf A, García J. Hemofilia adquirida. Permanyer: Ciudad de México; 2020.
Ceresetto JM, Duboscq C, Fondevila C, Tezanos-Pinto M. Hemofilia adquirida (inhibidor adquirido del factor VIII). Rev Medicina (B. Aires). 2015;75(4):231-238.
Giangrande P. Hemofilia Adquirida. Federación mundial de hemofilia: Quebéc, Canada; 2012.
Cohen Tervaert JW. Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld’s syndrome): A new flame. Autoimmun Rev. 2018;17(12):1259-64.
Article Sidebar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors retain their copyright and grant the Revista Médica del IMSS the right of first publication. Articles are distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows sharing as long as the author and the original source are properly credited.