Obstetric-gynecological and social factors for the development of cervical intraepithelial neoplasia
DOI:
https://doi.org/10.5281/zenodo.12667984Keywords:
Lesiones Intraepiteliales Escamosas del Cuello Uterino, Factores de Riesgo, Lesiones Precancerosas / Squamous Intraepithelial Lesions of the Cervix, Risk Factors, Precancerous ConditionsAbstract
Background: Cervical intraepithelial neoplasia (CIN) precedes cervical cancer and it is associated with risk factors that can be identified in the population, which contribute to timely diagnosis and treatment.
Objective: To identify associated risk factors for the development of CIN in women attended at the first level of care.
Material and methods: A cross-sectional and retrospective study was conducted in women in the 2020-2022 period. Frequencies and means were obtained. For the differences, chi-squared and Student’s t were used. Odds ratios (OR) were obtained to assess the risk.
Results: ORs were determined in the group of women with CIN II/CIN III, obtaining risks of almost twice the risk factors analyzed compared to the CIN I group, which had the same factors. When analyzed by age groups < or > 40 years, significant associations were determined in the factors of parity, first cytology in life and positive for smoking. In the group < 40 years and with CIN II/III significant risks were determined in age at first pregnancy < 18 (OR 8.33), first cytology in life (OR 3.77), positive for smoking (OR 3.0), sexual intercourse initiation (SII) before 18 years of age (OR 3.1) and parity (OR 1.3).
Conclusions: According to the results obtained, sexual and reproductive behavioral factors are of high risk for the development of CIN.
Downloads
References
International Agency for Research on Cancer. The Global Cancer Observatory. [sin lugar de publicación]: IARC; 2024. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/populations/484-mexico-fact-sheet.pdf.
Instituto Mexicano del Seguro Social. Base de datos del Registro Institucional de Cáncer de la Unidad de Medicina Familiar No. 15 del periodo 2020-2022. México: IMSS; 2020-2022.
Heredia-Caballero AG, Palacios-López GG, Castillo-Hernández MC. Prevalencia y tipificación de genotipos de virus del papiloma humano en mujeres del área metropolitana del Valle de México. Ginecol Obstet Mex. 2017;85(12):809-18. doi: 10.24245/gom.v85i12.1537.
Campos-Romero A, Anderson K, Longatto-Filho A, et al. The burden of 14 hr-HPV genotypes in women attending routine cervical cancer screening in 20 states of Mexico: a cross-sectional study. Scientific Reports, 2019;9:10094. doi: 10.1038/s41598-019-46543-8.
Soto-Fuenzalida GA, Hernández-Hernández JA, López-Sánchez RC, et al. Tipificación de serotipos del virus del papiloma humano de alto riesgo. Ginecol Obstet Mex. 2020; 88 (10): 659-66. doi: 10.24245/gom. v88i10.3432.
Gutierrez Campos R, Malacara Rosas A, Gutierrez Santillan E, et al. Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico. PLoS ONE 2019;14(4):e0215222. doi: 10.1371/journal.pone.0215222.
Adcock R, Cuzick J, Hunt W. et al. Role of HPV Genotype, Multiple Infections, and Viral Load on the Risk of High-Grade Cervical Neoplasia. Cancer Epidemiol Biomarkers Prev. 2019;28(11):1816-1824. doi: 10.1158/1055-9965.
Molina-Pineda A, López-Cardona MG, Limón-Toledo LP. High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. BMC Infect Dis. 2020;20(1):889. doi: 10.1186/s12879-020-05627-x.
Huang J, Deng Y, Boakye D. et al. Global distribution, risk factors, and recent trends for cervical cancer: A worldwide country-level analysis. Gynecol Oncol. 2022;164(1):85-92. doi: 10.1016/j.ygyno.2021.11.005.
Olubodun T, Balogun M R, Olowoselu OI. Et al. Cervical Cancer Knowledge, Risk Factors and Screening Practices among Women Residing in Urban Slums of Lagos, Southwest, Nigeria. West Afr J Med. 2022;39(6):595-602.
Mohammed H Al-Azri , Maytha Al-Saidi. Et al. Knowledge of Risk Factors, Symptoms and Barriers to Seeking Medical Help for Cervical Cancer among Omani Women Attending Sultan Qaboos University Hospital. Sultan Qaboos Univ Med J. 2020;20(3):e301-9. doi: 10.18295/squmj.2020.20.03.009.
Hernández-Rosas F, Orozco-Hernández E, Maza-Sánchez L. Prevalence and correlation of human papillomavirus genotypes with clinical factors in cervical samples from Mexican women. Exp Biol Med (Maywood). 2021;246(1):48-56. doi: 10.1177/1535370220959747.
Kalliala I, Athanasiou A, Veroniki AA, et al. Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature. Ann Oncol. 2020;31(2):213-27. doi: 10.1016/j.annonc.2019.11.004.
Ledesma-López V, López-Casamichana M, Fragozo-Sandoval F, et al. Perfil epidemiológico y algunas determinantes sociales de mujeres mexicanas con lesiones intraepiteliales cervicales en el Hospital Juárez de México y la Clínica Integral de la Mujer. Revista del Hospital Juárez de México. 2017;84(2):70-6.
Min KJ, Lee JK, So KA, et al. Association Between Passive Smoking and the Risk of Cervical Intraepithelial Neoplasia 1 in Korean Women. J Epidemiol. 2018;28(1):48-53. doi: 10.2188/jea.JE20160118
Sánchez-Ledesma R, Fernández-Martínez LC, Rodríguez-Gómez MR et al. Factores de riesgo del cáncer cérvico- uterino en San Juan y Martínez. Rev Ciencias Médicas, 2021;25(6):e5287.
Seefoó-Jarquín P, Sosa-Jurado F, Maycotte-González P. Panorama epidemiológico de las displasias cervicales en una unidad de primer nivel de atención. Rev Med Inst Mex Seguro Soc. 2023;61(2):155-62. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395894/pdf/04435117-61-2-155.pdf
Gallegos-Toribio R, Fuentes-Vargas MA, Gonzales-Menéndez MJM. Factores del estilo de vida predisponentes a displasia cervical en mujeres atendidas en el Hospital María Auxiliadora. Rev Fac Med Hum. 2019;19(2):48-56. doi: 10.25176/RFMH.v19.n2.2065
Torreglosa-Hernández S, Grisales-Romero H, Morales-Carmona E, et al. Supervivencia y factores asociados en pacientes con cáncer cervicouterino atendidas por el Seguro Popular en México. Salud Publica Mex. 2022;64:76-86. doi: 10.21149/131.8
Mendoza KG, Cunningham KW. Factores de riesgos en mujeres diagnosticadas con lesiones pre-malignas de cáncer cérvicouterino. Revista Universitaria Del Caribe. 2019;21(2):71-83. doi: 10.5377/ruc.v21i2.776
Bowden SJ, Doulgeraki T, Bouras E. Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies. BMC Medicine. 2023;21:274. doi: 10.1186/s12916-023-02965-w
Torres-Poveda K, Ruiz-Fraga I, Madrid-Marina V, et al. High risk HPV infection prevalence and associated cofactors: a population- based study in female ISSSTE beneficiaries attending the HPV screening and early detection of cervical cancer program. BMC Cancer. 2019;12:1250. doi: 10.1186/s12885-019-6388-4
Luciani S, Bruni L, Agurto I, et al. HPV vaccine implementation and monitoring in Latin America. Salud Publica Mex. 2018;60(6):683-92. doi: 10.21149/9090
Frietze G, Oliva R, Shenberger-Trujillo JM. Human Papillomavirus (HPV) Vaccine acceptability in Hispanic males living on the U.S./Mexico border. Hisp Health Care Int. 2021;19(1):55:56. doi: 10.1177/1540415320921479
Downloads
Published
Versions
- 2025-06-16 (2)
- 2024-08-30 (1)
Issue
Section
License
Copyright (c) 2024 Revista Médica del Instituto Mexicano del Seguro Social

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors retain their copyright and grant the Revista Médica del IMSS the right of first publication. Articles are distributed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows sharing as long as the author and the original source are properly credited.