Considerations on hypoxia and altitude
Main Article Content
Keywords
Altitude, Blood Gas Analysis, Oxygenation, Hypoxia, Resident Population
Abstract
Hypoxia associated with altitude is known as hypobaric hypoxia and it is related to the decrease in barometric pressure and inspired oxygen pressure; as they decrease, hypoxia increases. High altitude inhabitants acclimatise-adapt with morphological, physiological and genetic changes over generations. There are major differences between high altitude, moderate altitude and sea level. The characteristics of inhabitants of places with moderate altitude have been considered similar to those who live at sea level. However, hypobaric hypoxia is present and oxygenation is lower than at sea level, and it is still unknown what other changes may be caused by hypobaric hypoxia at this altitude.
References
1. Petersson J, Glenny RW. Gas Exchange in the Lung. Semin Respir Crit Care Med 2023; 44:555-68. doi:10.1055/s-0043-1770060.
2. Murillo JC, Salinas SC, López MJJ, et al. Función ventricular derecha en residentes nativos a gran altura. J Health Med Sci. 2020;6(2):113-22.
3. Santos-Martínez LE, Gómez-Tejeda RA, Murillo-Jauregui CX, et al. Exposición crónica a la altitud. Características clínicas y diagnóstico. Arch Cardiol Mex. 2021;91(4):500-7. doi: 10.24875/ACM.20000447.
4. Vizcarra-Vizcarra CA, Pérez-Quispe EC, Pilco-Prado LE, et al. Fisiología de altura. ¿Afecta la altura a la homeostasis? Rev Cuerpo Med HNAAA. 2024;16(4):1-22. doi: 10.35434/rcmhnaaa.2023.164.1866.
5. Viruez-Soto JA, Jiménez-Torres F, Sirpa-Choquehuanca V, et al. Gasometría arterial en residentes a gran altura, El Alto – Bolivia 2020. Cuad Hosp Clin. 2020;61(1):38-43.
6. Matthay MA, Arabi Y, Arroliga AC, et al. A New global definition of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2024;209(1):37-47. doi: 10.1164/rccm.202303-0558WS.
7. Perez-Padilla JR. Adaptation to moderate altitude hypoxemia: The example of the valley of Mexico. Rev Invest Clin. 2022;74(1):4-15. doi: 10.24875/RIC.21000159.
8. Santos-Martínez LE, Arias-Jiménez A, Quevedo-Paredes J, et al. Caracterización de los parámetros del intercambio gaseoso en la ciudad de México. Rev Med Inst Mex Seguro Soc. 2021;59(6):473-81. Disponible en: https://docs.bvsalud.org/biblioref/2022/02/1354772/4106-28306-1-pb-06-03.pdf.
9. Sandot A, Bunel V, Mal H. Indications of home oxygen therapy for patients with COPD or ILD. Rev Mal Respir. 2024;41(10):751-61. doi: 10.1016/j.rmr.2024.10.004.
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